Electrically stimulated 3D Scaffold for Bone Regeneration

Bone regeneration presents a major medical challenge, particularly after severe accidents, complex fractures, or orthopedic surgeries. In many cases, conventional treatment methods reach their limits. The RESBONREG research project, therefore, pursues an innovative approach to develop new ways of better supporting natural bone healing. The project focuses on novel three-dimensional, nanostructured biomaterials, so-called Janus fibers. These materials mimic the natural environment in which cells grow, organize, and form new tissue. The unique structure of the Janus fibers allows for the separate storage of different active substances, such as drugs or growth factors, within the material. A key innovative aspect of RESBONREG is the targeted release of these active substances through external stimuli. The developed scaffold structures respond to environmental changes such as electrical signals or pH fluctuations, enabling the controlled and demand- based release of stored substances. In this way, the biomaterial itself is actively integrated into the regeneration process. Controlled electrical stimulation is also employed. Electrical signals, similar to those found in the human body, affect both cells and the material. To better understand how cells respond to this electrical stimulation, computer simulations are used. These simulations help to analyze the effects of the electrical signals on cell behavior and to optimize the stimulation. All work in the RESBONREG project is conducted exclusively in in-vitro experiments, meaning in cell cultures in the laboratory. The findings provide an important scientific basis for future developments in regenerative medicine and can contribute to the long-term improvement of bone healing therapies.