Molecular Mechanisms of Cell Signaling
Molecular Mechanisms of Cell Signaling
Disciplines
Biology (75%); Medical-Theoretical Sciences, Pharmacy (25%)
Keywords
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Signaling,
Signaling Complexes,
Signaling Cascades,
Signaling Platforms (Cytoskeleton),
Signaling Cross-Talk,
Signal Specifity
Cells manage to survive, proliferate, and differentiate in their environment by interpreting the signals they receive from it and translating them into the right output. If signaling goes awry, even only in part of the cells, the whole organism is at risk. The MFPL is home to a strong group of internationally recognized scientists that use a combination of biochemistry, molecular biology, cell biology, and genetics to study cell signaling in different experimental systems including yeast, plants, mammalian cells and mice. The planned doctoral program concentrates on two main questions of this complex field: i) the impact of post-translational modifications, complex formation, and subcellular localization on the biogenesis and regulation of signaling networks and of the enzymes they comprise; and ii) the mechanisms by which distinct cascades, such as those that signal proliferation, interact with others signaling differentiation, stress, or inflammation. Finding the answers to these questions requires a comprehensive, state-of-the art multi-disciplinary approach. The proposed program is designed to meet the needs of the next generation of signal transduction researchers. Key features of the program will be: 1. Competitive selection of PhD students and supervisors 2. In-depth expert training in signal transduction, combined with cross-disciplinary training under the umbrellaof the International VBC Program, with which the Program will be associated 3. Individualized training on site and abroad, according to individual needs and interests 4. Extensive training in communication skills and training in management skills 5. Supervision by a PhD Thesis Committee (at least 3 PIs chosen by the student on the basis of their scientific background and expertise) 6. Extensive support for the communication of students with the international scientific community through participation in workshops and meetings 7. Intensive, regular contacts between the Cell Signaling Faculty and students, as well as among the students, to foster corporate identity and collaborative research. This blend of technological and transferable skills, together with the strong elements of networking at the local and global level, will equip the students with a competitive professional profile and increase their career chances.
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consortium member (01.05.2009 - 31.10.2015)
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consortium member (01.05.2009 - 31.10.2015)
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consortium member (01.05.2009 - 31.10.2015)
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consortium member (01.05.2009 - 31.10.2015)
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consortium member (01.05.2009 - 31.10.2015)
- Medizinische Universität Wien
- Universität Wien
- Wolfram Weckwerth, Universität Wien , national collaboration partner
- Erwin F. Wagner, Medizinische Universität Wien , national collaboration partner
- Jiri Friml, Institute of Science and Technology Austria - ISTA , national collaboration partner
- Roland Foisner, Medizinische Universität Wien , associated research partner
- Estelle Sontag, University of Newcastle - Australia
- Liliane Schoofs, Katholieke Universiteit Leuven - Belgium
- Anne-Claude Gingras, Mount Sinai Hospital - Canada
- James R. Davie, University of Manitoba - Canada
- Pavel Hozak, Academy of Sciences of the Czech Republic - Czechia
- Fulvio Reggiori, Aarhus University - Denmark
- Guillaume Balavoine, Université Paris Diderot - Paris 7 - France
- Fatiha Nothias, Universite Pierre et Marie Curie - France
- Alain Eychene, Université Paris Sud - France
- Simonetta Piatti, Centre National de la Recherche Scientifique - France
- Gisèle Bonne, INSERM U 582 - France
- Rolf Schröder, Universitätsklinikum Erlangen - Germany
- Bettina Warscheid, Universität Freiburg - Germany
- Carsten J. Kirschning, Universität Essen - Germany
- Jörg Höhfeld, Universität Bonn - Germany
- Dieter O. Fürst, Universität Bonn - Germany
- Dieter Saur, Technische Universität München - Germany
- Juri Rappsilber, Technische Universität Berlin - Germany
- Carsten Schultz, Ruprecht-Karls-Universität Heidelberg - Germany
- Markus Engstler, Technische Universität Darmstadt - Germany
- Peter J. Murray, Max-Planck-Gesellschaft - Germany
- Emmanuelle Charpentier, Max-Planck-Gesellschaft - Germany
- Oliver Daumke, Max Delbrück Centrum für molekulare Medizin - Germany
- Lars Dölken, Julius-Maximilians-Universität Würzburg - Germany
- Frank Bradke, Helmholtzgesellschaft - Germany
- Dmitri I. Svergun, European Molecular Biology Laboratory Hamburg - Germany
- Detlev Arendt, European Molecular Biology Laboratory - Germany
- Harald Herrmann-Lerdon, Deutsches Krebsforschungszentrum - Germany
- Wolfgang Fischle, Max-Planck-Gesellschaft - Germany
- Walter Kolch, University College of Dublin - Ireland
- Yuwal Garini, Bar-Ilan University - Israel
- Maria Ina Arnone, Stazione Zoologica Anton Dohrn - Italy
- Giovanna Lattanzi, Consiglio Nazionale delle Ricerche - Italy
- Susanna Chiocca, European Institute of Oncology Milano - Italy
- Giuseppe Novelli, National Agency for the Evaluation of Universities and Research Institutes - Italy
- Harald Hausen, Bergen High Technology Centre - Norway
- Bartosz Rozycki, Polish Academy of Sciences - Poland
- Maria Carmo-Fonseca, University of Lisbon - Portugal
- Mariano Barbacid, Centro National de Investigaciones Oncologicas - Spain
- Ethel Queralt, Institut d´Investigació Biomédica de Bellvitge (IDIBELL) - Spain
- José A. Bengoechea, Recinte Hospital Joan March - Spain
- Francesc Posas, Universitat Pompeu Fabra - Spain
- Eulalia De Nadal Clanchet, Universitat Pompeu Fabra - Spain
- Sofia Johansson, Karolinska Institute - Sweden
- Birthe Fahrenkrog, Universität Basel - Switzerland
- Greta Guarda, University of Lausanne - Switzerland
- Josef Jiricny, University of Zurich - Switzerland
- Ruedi Aebersold, ETH Zürich - Switzerland
- Matthias Peter, ETH Hönggerberg - Switzerland
- Patrick Matthias, Friedrich Miescher Institute for Biomedical Research - Switzerland
- Ron D. Vale, University of California at San Francisco - USA
- Ruslan Medzhitov, Yale University School of Medicine - USA
- Elisabetta Ullu, Yale University School of Medicine - USA
- Robert D. Schreiber, Washington University School of Medicine - USA
- Yongna Xing, University of Wisconsin-Madison - USA
- Wenqing Xu, University of Washington - USA
- Stanley C. Froehner, University of Washington - USA
- Dylan Taatjes, University of Colorado Boulder - USA
- Marsha R. Rosner, University of Chicago - USA
- Kevan M. Shokat, University of California at San Francisco - USA
- James T. Kadonaga, University of California, San Diego - USA
- Karsten Sauer, The Scripps Research Institute - USA
- Robert D. Goldman, Northwestern University - USA
- David E. Levy, New York University School of Medicine - USA
- Perry J. Blackshear, National Institute of Environmental Health Sciences - USA
- Michael M. Bustin, National Cancer Institute / NIH - USA
- James E. Bradner, Harvard Medical School - USA
- Christian Schindler, Columbia University New York - USA
- George R. Stark, Cleveland Clinic - USA
- Amanda Jamieson, Brown University - USA
- James H. Hurley, University of California Berkeley - USA
- Uwe Vinkemeier, University of Nottingham - United Kingdom
- Adele Marston, University of Edinburgh - United Kingdom
- Michael A. J. Ferguson, University of Dundee - United Kingdom
- Omar Qureshi, The University of Birmingham - United Kingdom
- Harvey T. Mcmahon, Medical Research Council - United Kingdom
- David Barford, Medical Research Council - United Kingdom
- Julian Downward, Imperial Cancer Research Fund - United Kingdom
- Mathias Gautel, King´s College London - United Kingdom
- Jonathon Pines, Institute of Cancer Research - United Kingdom
- Sharon Tooze, Francis Crick Institute - United Kingdom
- Christopher J. Hutchison, Durham University - United Kingdom
- David Tuveson, Cancer Research UK - United Kingdom
- Tony Ng, King´s College London - United Kingdom
Research Output
- 16325 Citations
- 65 Publications
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2016
Title Molecular insights into the premature aging disease progeria DOI 10.1007/s00418-016-1411-1 Type Journal Article Author Vidak S Journal Histochemistry and Cell Biology Pages 401-417 Link Publication -
2016
Title Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals DOI 10.1186/s12860-016-0102-z Type Journal Article Author Zlopasa L Journal BMC Cell Biology Pages 23 Link Publication -
2017
Title Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2a in progeria cells DOI 10.1242/jcs.208462 Type Journal Article Author Vidak S Journal Journal of Cell Science Link Publication -
2016
Title Essential Nonredundant Function of the Catalytic Activity of Histone Deacetylase 2 in Mouse Development DOI 10.1128/mcb.00639-15 Type Journal Article Author Hagelkruys A Journal Molecular and Cellular Biology Pages 462-474 Link Publication -
2015
Title Promoter Occupancy of STAT1 in Interferon Responses Is Regulated by Processive Transcription DOI 10.1128/mcb.01097-14 Type Journal Article Author Wiesauer I Journal Molecular and Cellular Biology Pages 716-727 Link Publication -
2015
Title Repulsive Axon Guidance by Draxin Is Mediated by Protein Kinase B (Akt), Glycogen Synthase Kinase-3ß (GSK-3ß) and Microtubule-Associated Protein 1B DOI 10.1371/journal.pone.0119524 Type Journal Article Author Meli R Journal PLOS ONE Link Publication -
2014
Title A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog DOI 10.1242/dev.100487 Type Journal Article Author Hagelkruys A Journal Development Pages 604-616 Link Publication -
2014
Title H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress DOI 10.1101/gr.176255.114 Type Journal Article Author Sawicka A Journal Genome Research Pages 1808-1820 Link Publication -
2014
Title Sensing core histone phosphorylation — A matter of perfect timing DOI 10.1016/j.bbagrm.2014.04.013 Type Journal Article Author Sawicka A Journal Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Pages 711-718 Link Publication -
2015
Title Alike but Different: RAF Paralogs and Their Signaling Outputs DOI 10.1016/j.cell.2015.04.045 Type Journal Article Author Desideri E Journal Cell Pages 967-970 Link Publication -
2015
Title Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2a (LAP2a) through expression of extracellular matrix proteins DOI 10.1101/gad.263939.115 Type Journal Article Author Vidak S Journal Genes & Development Pages 2022-2036 Link Publication -
2015
Title Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2 DOI 10.1371/journal.pone.0119727 Type Journal Article Author Fieber C Journal PLOS ONE Link Publication -
2014
Title “RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway DOI 10.1016/j.febslet.2014.06.025 Type Journal Article Author Cseh B Journal FEBS Letters Pages 2398-2406 Link Publication -
2013
Title Difficulties in Generating Specific Antibodies for Immunohistochemical Detection of Nitrosylated Tubulins DOI 10.1371/journal.pone.0068168 Type Journal Article Author Kamnev A Journal PLoS ONE Link Publication -
2012
Title Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection DOI 10.1371/journal.ppat.1002763 Type Journal Article Author Kernbauer E Journal PLoS Pathogens Link Publication -
2012
Title The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo DOI 10.1242/jcs.098392 Type Journal Article Author Brachner A Journal Journal of Cell Science Pages 1048-1057 Link Publication -
2012
Title M-Track: detecting short-lived protein-protein interactions in vivo DOI 10.1038/nmeth.2017 Type Journal Article Author Zuzuarregui A Journal Nature Methods Pages 594-596 Link Publication -
2012
Title Histone H3 phosphorylation – A versatile chromatin modification for different occasions DOI 10.1016/j.biochi.2012.04.018 Type Journal Article Author Sawicka A Journal Biochimie Pages 2193-2201 Link Publication -
2013
Title Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis DOI 10.1038/emboj.2013.243 Type Journal Article Author Winter M Journal The EMBO Journal Pages 3176-3191 Link Publication -
2012
Title Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation DOI 10.1126/science.1225967 Type Journal Article Author Wang R Journal Science Pages 956-959 Link Publication -
2012
Title Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy DOI 10.1155/2012/736905 Type Journal Article Author Lamark T Journal International Journal of Cell Biology Pages 736905 Link Publication -
2012
Title A Downstream CpG Island Controls Transcript Initiation and Elongation and the Methylation State of the Imprinted Airn Macro ncRNA Promoter DOI 10.1371/journal.pgen.1002540 Type Journal Article Author Koerner M Journal PLoS Genetics Link Publication -
2012
Title Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1 DOI 10.1016/j.chom.2012.07.012 Type Journal Article Author Qualls J Journal Cell Host & Microbe Pages 313-323 Link Publication -
2013
Title Transcription and beyond: the role of mammalian class I lysine deacetylases DOI 10.1007/s00412-013-0441-x Type Journal Article Author Moser M Journal Chromosoma Pages 67-78 Link Publication -
2013
Title CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response DOI 10.1016/j.immuni.2012.10.017 Type Journal Article Author Bancerek J Journal Immunity Pages 250-262 Link Publication -
2013
Title Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes DOI 10.1091/mbc.e12-06-0488 Type Journal Article Author Valencia R Journal Molecular Biology of the Cell Pages 768-784 Link Publication -
2013
Title Lamina-associated polypeptide (LAP)2a and nucleoplasmic lamins in adult stem cell regulation and disease DOI 10.1016/j.semcdb.2013.12.009 Type Journal Article Author Gesson K Journal Seminars in Cell & Developmental Biology Pages 116-124 Link Publication -
2013
Title An analogue-sensitive approach identifies basal body rotation and flagellum attachment zone elongation as key functions of PLK in Trypanosoma brucei DOI 10.1091/mbc.e12-12-0846 Type Journal Article Author Lozano-Núñez A Journal Molecular Biology of the Cell Pages 1321-1333 Link Publication -
2013
Title MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance DOI 10.1016/j.molcel.2013.01.037 Type Journal Article Author Zmajkovicova K Journal Molecular Cell Pages 43-55 Link Publication -
2013
Title The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection DOI 10.1371/journal.pone.0060476 Type Journal Article Author Köprülü A Journal PLoS ONE Link Publication -
2014
Title Responses of innate immune cells to group A Streptococcus DOI 10.3389/fcimb.2014.00140 Type Journal Article Author Fieber C Journal Frontiers in Cellular and Infection Microbiology Pages 140 Link Publication -
2014
Title Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle DOI 10.1172/jci71919 Type Journal Article Author Winter L Journal Journal of Clinical Investigation Pages 1144-1157 Link Publication -
2014
Title CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2 DOI 10.1038/ni.2864 Type Journal Article Author Boucheron N Journal Nature Immunology Pages 439-448 Link Publication -
2014
Title Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes DOI 10.1091/mbc.e14-06-1174 Type Journal Article Author Mihailovska E Journal Molecular Biology of the Cell Link Publication -
2015
Title Plectin isoform 1-dependent nuclear docking of desmin networks affects myonuclear architecture and expression of mechanotransducers DOI 10.1093/hmg/ddv438 Type Journal Article Author Staszewska I Journal Human Molecular Genetics Pages 7373-7389 Link Publication -
2012
Title In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells DOI 10.1101/gad.184648.111 Type Journal Article Author Fonseca J Journal Genes & Development Pages 857-871 Link Publication -
2012
Title Both TLR2 and TRIF Contribute to Interferon-ß Production during Listeria Infection DOI 10.1371/journal.pone.0033299 Type Journal Article Author Aubry C Journal PLoS ONE Link Publication -
2012
Title Polo-like kinase is necessary for flagellum inheritance in Trypanosoma brucei DOI 10.1242/jcs.101162 Type Journal Article Author Ikeda K Journal Journal of Cell Science Pages 3173-3184 Link Publication -
2011
Title Chaperone-Mediated Autophagy Is Required for Tumor Growth DOI 10.1126/scitranslmed.3003182 Type Journal Article Author Kon M Journal Science Translational Medicine Link Publication -
2011
Title The Biology of HDAC in Cancer: The Nuclear and Epigenetic Components DOI 10.1007/978-3-642-21631-2_2 Type Book Chapter Author Hagelkruys A Publisher Springer Nature Pages 13-37 -
2011
Title Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis DOI 10.4161/cc.10.3.14712 Type Journal Article Author Jurkin J Journal Cell Cycle Pages 406-412 Link Publication -
2011
Title Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation DOI 10.1038/msb.2011.93 Type Journal Article Author Kratochvill F Journal Molecular Systems Biology Link Publication -
2010
Title MAPK Phosphatase AP2C3 Induces Ectopic Proliferation of Epidermal Cells Leading to Stomata Development in Arabidopsis DOI 10.1371/journal.pone.0015357 Type Journal Article Author Umbrasaite J Journal PLoS ONE Link Publication -
2010
Title Epigenetic Regulation of a Murine Retrotransposon by a Dual Histone Modification Mark DOI 10.1371/journal.pgen.1000927 Type Journal Article Author Brunmeir R Journal PLoS Genetics Link Publication -
2010
Title Tubulohelical membrane arrays: From the initial observation to the elucidation of nanophysical properties and cellular function DOI 10.1186/1757-5036-3-13 Type Journal Article Author Reipert S Journal PMC Biophysics Pages 13 Link Publication -
2010
Title Lamina-Independent Lamins in the Nuclear Interior Serve Important Functions DOI 10.1101/sqb.2010.75.018 Type Journal Article Author Dechat T Journal Cold Spring Harbor Symposia on Quantitative Biology Pages 533-543 Link Publication -
2010
Title A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors* DOI 10.1074/jbc.m110.184481 Type Journal Article Author Simboeck E Journal Journal of Biological Chemistry Pages 41062-41073 Link Publication -
2010
Title Nonconventional Initiation Complex Assembly by STAT and NF-?B Transcription Factors Regulates Nitric Oxide Synthase Expression DOI 10.1016/j.immuni.2010.07.001 Type Journal Article Author Farlik M Journal Immunity Pages 25-34 Link Publication -
2010
Title Monoclonal Antibodies Specific for Disease-Associated Point-Mutants: Lamin A/C R453W and R482W DOI 10.1371/journal.pone.0010604 Type Journal Article Author Roblek M Journal PLoS ONE Link Publication -
2009
Title Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes DOI 10.1371/journal.ppat.1000355 Type Journal Article Author Stockinger S Journal PLoS Pathogens Link Publication -
2009
Title Targeted Inactivation of a Developmentally Regulated Neural Plectin Isoform (Plectin 1c) in Mice Leads to Reduced Motor Nerve Conduction Velocity* DOI 10.1074/jbc.m109.018150 Type Journal Article Author Fuchs P Journal Journal of Biological Chemistry Pages 26502-26509 Link Publication -
2008
Title Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens DOI 10.1016/j.chom.2008.10.003 Type Journal Article Author Zhao Z Journal Cell Host & Microbe Pages 458-469 Link Publication -
2011
Title Biological challenges of BRAF inhibitor therapy DOI 10.1016/j.molonc.2011.01.005 Type Journal Article Author Puzanov I Journal Molecular Oncology Pages 116-123 Link Publication -
2011
Title Regulation of protein kinases by lipids DOI 10.1016/j.sbi.2011.07.006 Type Journal Article Author Leonard T Journal Current Opinion in Structural Biology Pages 785-791 Link Publication -
2011
Title LipA, a Tyrosine and Lipid Phosphatase Involved in the Virulence of Listeria monocytogenes DOI 10.1128/iai.05073-11 Type Journal Article Author Kastner R Journal Infection and Immunity Pages 2489-2498 Link Publication -
2011
Title Autophagy-deficient mice develop multiple liver tumors DOI 10.1101/gad.2016211 Type Journal Article Author Takamura A Journal Genes & Development Pages 795-800 Link Publication -
2011
Title Histone Deacetylases: the Biology and Clinical Implication DOI 10.1007/978-3-642-21631-2 Type Book Publisher Springer Nature -
2011
Title Generation of mice with a conditional Stat1 null allele DOI 10.1007/s11248-011-9519-5 Type Journal Article Author Wallner B Journal Transgenic Research Pages 217-224 -
2011
Title The “SWOT” of BRAF Inhibition in Melanoma: RAF Inhibitors, MEK Inhibitors or Both? DOI 10.1007/s11912-011-0198-4 Type Journal Article Author Nissan M Journal Current Oncology Reports Pages 479-487 -
2010
Title Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans DOI 10.1038/emboj.2010.264 Type Journal Article Author Lagger S Journal The EMBO Journal Pages 3992-4007 Link Publication -
2010
Title Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance DOI 10.1016/j.cub.2009.11.022 Type Journal Article Author Arndt V Journal Current Biology Pages 143-148 Link Publication -
2010
Title BRAF Inhibitors: Research Accelerates in Wake of Positive Findings DOI 10.1093/jnci/djq037 Type Journal Article Author Brower V Journal Journal of the National Cancer Institute Pages 214-215 Link Publication -
2009
Title Listeria monocytogenes ActA-mediated escape from autophagic recognition DOI 10.1038/ncb1967 Type Journal Article Author Yoshikawa Y Journal Nature Cell Biology Pages 1233-1240 -
2002
Title Mutations of the BRAF gene in human cancer DOI 10.1038/nature00766 Type Journal Article Author Davies H Journal Nature Pages 949-954 -
2021
Title DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis DOI 10.15252/embj.2021108234 Type Journal Article Author Beck M Journal The EMBO Journal Link Publication