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  • de Wechsle zu Deutsch

  

Molecular Enzymology: Stucture, Function and Biotechnological Exploitation of Enzymes

Molecular Enzymology: Stucture, Function and Biotechnological Exploitation of Enzymes

Ellen L. Zechner (ORCID: 0000-0003-2035-1898)
  • Grant DOI 10.55776/W901
  • Funding program Doctoral Programs
  • Status ended
  • Start May 1, 2005
  • End June 30, 2019
  • Funding amount € 13,525,460
  • E-mail

Disciplines

Biology (100%)

Consortium
  • Bernd Nidetzky, Technische Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Birgit Wiltschi, Universität für Bodenkultur Wien
    consortium member (01.05.2005 - 30.06.2019)
  • Ellen L. Zechner, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Günther Daum, Technische Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Karl Gruber, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Klaus Zangger, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Kurt Faber, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Monika Oberer, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Robert Zimmermann, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Rolf Breinbauer, Technische Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Rudolf Zechner, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Sepp Dieter Kohlwein, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Stefan Schild, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
  • Wolfgang Kroutil, Universität Graz
    consortium member (01.05.2005 - 30.06.2019)
Research institution(s)
  • Universität Graz
  • Universität Graz
  • Universität Graz
  • Technische Universität Graz
  • Technische Universität Graz
  • Technische Universität Graz
  • Technische Universität Graz
  • Technische Universität Graz
  • Universität Graz
Project participants
  • Tobias Madl, Medizinische Universität Graz , national collaboration partner
  • Ronald Philip Kühnlein, Universität Graz , national collaboration partner
  • Erwin F. Wagner, Medizinische Universität Wien , national collaboration partner
  • Peter Macheroux, Technische Universität Graz , associated research partner
International project participants
  • Laurence Van Melderen, Université Libre de Bruxelles - Belgium
  • Remy Loris, Vrije Universiteit Brussel - Belgium
  • Brenda Andrews, University of Toronto - Canada
  • Marija Abramic, Rudjer Boskovic Institute - Croatia
  • Reinhard Wimmer, Aalborg University - Denmark
  • John M. Woodley, The Technical University of Denmark - Denmark
  • Mikael Skurnik, Helsinki University - Finland
  • Pierre Golstein, CNRS de Marseille-Luminy - France
  • Guido Kroemer, INSERM U1138 - France
  • Alfred Pühler, Universität Bielefeld - Germany
  • Jens Timmer, Universität Freiburg - Germany
  • Nikolaus Pfanner, Universität Freiburg - Germany
  • Gerhard Liebisch, Universität Regensburg - Germany
  • Dieter H. Wolf, Universität Stuttgart - Germany
  • Christian Hübner, Universität zu Lübeck - Germany
  • Mathias Bureik, Universität des Saarlandes - Germany
  • Stephan A. Sieber, Technische Universität München - Germany
  • Judith Fischer, Universitätsklinikum Freiburg - Germany
  • Barbara Kappes, Universitätsklinikum Heidelberg - Germany
  • Andreas Friebe, Universitätsklinikum Würzburg - Germany
  • Manfred J. Schmidt, Universität des Saarlandes - Germany
  • Michael Groll, Technische Universität München - Germany
  • Matthias Frosch, Julius-Maximilians-Universität Würzburg - Germany
  • Andreas Daiber, Klinikum der Johannes-Gutenberg-Universität Mainz - Germany
  • Michael Karas, Johann Wolfgang Goethe Universität Frankfurt am Main - Germany
  • Markus Kollmann, Humboldt-Universität zu Berlin - Germany
  • Wulf Blankenfeldt, Helmholtz-Gemeinschaft Deutscher Forschungszentren - Germany
  • Matthias H. Tschöp, Helmholtz Zentrum München - Germany
  • Reza Ahmadian, Heinrich-Heine-Universität Düsseldorf - Germany
  • Martina Pohl, Heinrich-Heine-Universität Düsseldorf - Germany
  • Vlada B. Urlacher, Heinrich Heine Universität Düsseldorf - Germany
  • Ivo Feussner, Georg-August-Universität Göttingen - Germany
  • Ulrich Schwaneberg, DWI - Leibniz-Institut für Interaktive Materialien e.V. - Germany
  • Hanno Tröger, Charité - Campus Benjamin Franklin - Germany
  • Doris Koesling, Ruhr-Universität Bochum - Germany
  • Amit Kumar Das, Indian Institute of Technology Kharagpur - India
  • Wim J. Quax, University of Groningen - Netherlands
  • Marten Veenhuis, University of Groningen - Netherlands
  • Bauke W. Dijkstra, Rijksuniversiteit Groningen - Netherlands
  • Dick B. Janssen, University of Groningen - Netherlands
  • David L Silver, Duke-NUS Graduate Medical School Singapore - Singapore
  • Fernando De La Cruz, Universidad de Cantabria - Spain
  • Boris Zhivotovsky, Karolinska Institutet - Sweden
  • Peter Arner, Karolinska Institutet - Sweden
  • Hindrik Mulder, Lund University - Sweden
  • Sun Nyunt Wai, Umea University - Sweden
  • Anna Stina Sandelius, University of Gothenburg - Sweden
  • Donald Hilvert, ETH Zürich - Switzerland
  • Leo Eberl, University of Zurich - Switzerland
  • Roger Schneiter, Universität Freiburg - Switzerland
  • Romas J. Kazlauskas, University of Minnesota Medical School - USA
  • Lawrence P. Wackett, University of Minnesota - USA
  • Bruce A. Palfey, University of Michigan - USA
  • Jon D. Stewart, University of Florida - USA
  • Daniel K. Nomura, University of California Berkeley - USA
  • Jeffrey L. Brodsky, University of Pittsburgh - USA
  • Robert H. Eckel, University of Colorado Boulder - USA
  • Edward I. Solomon, University of Stanford - USA
  • Leslie B. Poole, Wake Forest University - USA
  • Peter J. Christie, University of Texas at Houston - USA
  • William Dowhan, University of Texas at Houston - USA
  • Beth Traxler, University of Washington - USA
  • David Baker, University of Washington - USA
  • David K. Wilson, University of California - USA
  • Mario F. Feldman, Washington University in St. Louis - USA
  • Steven E. Ealick, Weill Cornell Medical College - USA
  • Richard J. Meyer, University of Texas - USA
  • Teresa Dunn, Uniformed Services University of Health Sciences - USA
  • Bruce D. Hammock, University of California at Davis - USA
  • Karl E. Klose, The University of Texas at San Antonio - USA
  • Andrew Camilli, Tufts University - USA
  • Frances H. Arnold, California Institute of Technology - USA
  • Jonathan Mark Brown, Cleveland Clinic Foundation - USA
  • Anant K. Menon, Cornell University - USA
  • David G. Russell, Cornell University - USA
  • Susan A. Henry, Cornell University - USA
  • Dean E. Wilcox, Dartmouth College - USA
  • Toni M. Kutchan, Donald Danforth Plant Science Center - USA
  • David A. Tirrell, California Institute of Technology - USA
  • Gerhard Wagner, Harvard Medical School - USA
  • Wing Ming Keung, Harvard Medical School - USA
  • Sirano Dhe-Paganon, Harvard University - USA
  • Joel F. Schildbach, Johns Hopkins University - USA
  • Nico Tjandra, National Institutes of Health - USA
  • Ho-Leung Fung, State University of New York at Buffalo - USA
  • Benjamin F. Cravatt, The Scripps Research Institute - USA
  • Jennifer Lippincott-Schwartz, HHMI - USA
  • Gideon J. Grogan, University of York - United Kingdom
  • Ivo Tews, University of Southampton - United Kingdom
  • Benjamin G. Davis, University of Oxford - United Kingdom
  • Ingrid Dreveny, University of Nottingham - United Kingdom
  • Cameron D. Alexander, University of Nottingham - United Kingdom
  • Samuel De Visser, University of Manchester - United Kingdom
  • Nigel Scrutton, University of Manchester - United Kingdom
  • Nicholas J. Turner, University of Manchester - United Kingdom
  • Florian Hollfelder, University of Cambridge - United Kingdom
  • Peter J. Voshol, University of Cambridge - United Kingdom
  • Peter F. Leadlay, University of Cambridge - United Kingdom
  • Gabriel Waksman, University College London - United Kingdom
  • Udo Oppermann, The University of Oxford - United Kingdom
  • Jonathan D. G. Jones, John Innes Center - United Kingdom
  • Graham F. White, Cardiff University - United Kingdom
  • Andrew W. Munro, University of Manchester - United Kingdom

Research Output

  • 30851 Citations
  • 433 Publications
Publications
  • 2016
    Title Synthetic Core Promoters as Universal Parts for Fine-Tuning Expression in Different Yeast Species
    DOI 10.1021/acssynbio.6b00178
    Type Journal Article
    Author Portela R
    Journal ACS Synthetic Biology
    Pages 471-484
    Link Publication
  • 2016
    Title AAA+ proteases and their role in distinct stages along the Vibrio cholerae lifecycle
    DOI 10.1016/j.ijmm.2016.05.013
    Type Journal Article
    Author Pressler K
    Journal International Journal of Medical Microbiology
    Pages 452-462
  • 2016
    Title Additive-Free Pd-Catalyzed a-Allylation of Imine-Containing Heterocycles
    DOI 10.1021/acs.orglett.6b03407
    Type Journal Article
    Author Kljajic M
    Journal Organic Letters
    Pages 126-129
    Link Publication
  • 2016
    Title Sequential Enzymatic Conversion of a-Angelica Lactone to ?-Valerolactone through Hydride-Independent C=C Bond Isomerization
    DOI 10.1002/cssc.201601363
    Type Journal Article
    Author Turrini N
    Journal ChemSusChem
    Pages 3393-3396
    Link Publication
  • 2016
    Title Preparation of Homoallylic Alcohols via a Chemoenzymatic One-Pot Oxidation-Allylation Cascade.
    Type Book Chapter
    Author Fuchs M
  • 2016
    Title Binding pattern of intermediate UDP-4-keto-xylose to human UDP-xylose synthase: Synthesis and STD NMR of model keto-saccharides
    DOI 10.1016/j.carres.2016.11.001
    Type Journal Article
    Author Puchner C
    Journal Carbohydrate Research
    Pages 50-58
  • 2016
    Title An Esterase from Anaerobic Clostridium hathewayi Can Hydrolyze Aliphatic–Aromatic Polyesters
    DOI 10.1021/acs.est.5b04346
    Type Journal Article
    Author Perz V
    Journal Environmental Science & Technology
    Pages 2899-2907
  • 2016
    Title Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation
    DOI 10.1016/j.jid.2016.09.025
    Type Journal Article
    Author Grond S
    Journal Journal of Investigative Dermatology
    Pages 403-413
    Link Publication
  • 2016
    Title Downstream Processing of Nucleoside-Diphospho-Sugars from Sucrose Synthase Reaction Mixtures at Decreased Solvent Consumption
    DOI 10.1002/adsc.201600540
    Type Journal Article
    Author Lemmerer M
    Journal Advanced Synthesis & Catalysis
    Pages 3113-3122
  • 2016
    Title Conjugative DNA Transfer Is Enhanced by Plasmid R1 Partitioning Proteins
    DOI 10.3389/fmolb.2016.00032
    Type Journal Article
    Author Gruber C
    Journal Frontiers in Molecular Biosciences
    Pages 32
    Link Publication
  • 2016
    Title Monoacylglycerol Lipases Act as Evolutionarily Conserved Regulators of Non-oxidative Ethanol Metabolism
    DOI 10.1074/jbc.m115.705541
    Type Journal Article
    Author Heier C
    Journal Journal of Biological Chemistry
    Pages 11865-11875
    Link Publication
  • 2016
    Title Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p
    DOI 10.1016/j.bbalip.2016.02.005
    Type Journal Article
    Author Aschauer P
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 462-470
    Link Publication
  • 2016
    Title PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides
    DOI 10.1016/j.jid.2016.08.036
    Type Journal Article
    Author Grond S
    Journal Journal of Investigative Dermatology
    Pages 394-402
    Link Publication
  • 2016
    Title Structural characterization of a Vatairea macrocarpa lectin in complex with a tumor-associated antigen: A new tool for cancer research
    DOI 10.1016/j.biocel.2015.12.016
    Type Journal Article
    Author Sousa B
    Journal The International Journal of Biochemistry & Cell Biology
    Pages 27-39
    Link Publication
  • 2016
    Title Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products
    DOI 10.1021/acscatal.6b00758
    Type Journal Article
    Author Schmidt N
    Journal ACS Catalysis
    Pages 4286-4311
    Link Publication
  • 2016
    Title Intensifying the O2-dependent heterogeneous biocatalysis: Superoxygenation of solid support from H2O2 by a catalase tailor-made for effective immobilization
    DOI 10.1016/j.molcatb.2016.10.017
    Type Journal Article
    Author Bolivar J
    Journal Journal of Molecular Catalysis B: Enzymatic
    Pages 302-309
  • 2016
    Title Bacterial outer membrane vesicle biogenesis: a new mechanism and its implications
    DOI 10.15698/mic2016.06.508
    Type Journal Article
    Author Roier S
    Journal Microbial Cell
    Pages 257
    Link Publication
  • 2016
    Title Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism
    DOI 10.1194/jlr.m072538
    Type Journal Article
    Author Kory N
    Journal Journal of Lipid Research
    Pages 226-235
    Link Publication
  • 2016
    Title Integrated process design for biocatalytic synthesis by a Leloir Glycosyltransferase: UDP-glucose production with sucrose synthase
    DOI 10.1002/bit.26204
    Type Journal Article
    Author Schmölzer K
    Journal Biotechnology and Bioengineering
    Pages 924-928
  • 2015
    Title Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites
    DOI 10.1016/j.bbapap.2015.03.011
    Type Journal Article
    Author Bergner T
    Journal Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
    Pages 890-896
  • 2015
    Title Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism*
    DOI 10.1074/jbc.m115.659631
    Type Journal Article
    Author Daniel B
    Journal Journal of Biological Chemistry
    Pages 18770-18781
    Link Publication
  • 2014
    Title The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis*?
    DOI 10.1074/jbc.m114.604744
    Type Journal Article
    Author Pollak N
    Journal Journal of Biological Chemistry
    Pages 1295-1306
    Link Publication
  • 2014
    Title Endothelial dysfunction in adipose triglyceride lipase deficiency
    DOI 10.1016/j.bbalip.2014.03.005
    Type Journal Article
    Author Schrammel A
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 906-917
    Link Publication
  • 2014
    Title Phosphoryl Transfer from a-d-Glucose 1-Phosphate Catalyzed by Escherichia coli Sugar-Phosphate Phosphatases of Two Protein Superfamily Types
    DOI 10.1128/aem.03314-14
    Type Journal Article
    Author Wildberger P
    Journal Applied and Environmental Microbiology
    Pages 1559-1572
    Link Publication
  • 2020
    Title Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation
    DOI 10.1016/j.bbalip.2020.158730
    Type Journal Article
    Author Wagner C
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 158730
    Link Publication
  • 2019
    Title Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation
    DOI 10.1074/jbc.ra118.007201
    Type Journal Article
    Author Pajed L
    Journal Journal of Biological Chemistry
    Pages 9118-9133
    Link Publication
  • 2021
    Title Efficient Entropy-Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition-State Peptidomimetics
    DOI 10.1002/chem.202102204
    Type Journal Article
    Author Ivkovic J
    Journal Chemistry – A European Journal
    Pages 14108-14120
    Link Publication
  • 2021
    Title The periplasmic domains of Vibriocholerae ToxR and ToxS are forming a strong heterodimeric complex independent on the redox state of ToxR cysteines
    DOI 10.1111/mmi.14673
    Type Journal Article
    Author Gubensäk N
    Journal Molecular Microbiology
    Pages 1277-1291
    Link Publication
  • 2021
    Title Biofilms by bacterial human pathogens: Clinical relevance – development, composition and regulation – therapeutical strategies
    DOI 10.15698/mic2021.02.741
    Type Journal Article
    Author Schulze A
    Journal Microbial Cell
    Pages 28
    Link Publication
  • 2017
    Title Improved biooxidation of Benzyl alcohols catalyzed by the flavoprotein (5-Hydroxymethyl)furfural oxidase in organic solvents
    DOI 10.1016/j.tet.2017.07.038
    Type Journal Article
    Author Pickl M
    Journal Tetrahedron
    Pages 5408-5410
    Link Publication
  • 2017
    Title A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain
    DOI 10.1371/journal.pone.0188915
    Type Journal Article
    Author Hromic-Jahjefendic A
    Journal PLOS ONE
    Link Publication
  • 2017
    Title Expanding the CRISPR/Cas9 toolkit for Pichia pastoris with efficient donor integration and alternative resistance markers
    DOI 10.1002/jcb.26474
    Type Journal Article
    Author Weninger A
    Journal Journal of Cellular Biochemistry
    Pages 3183-3198
    Link Publication
  • 2017
    Title Library of Norcoclaurine Synthases and Their Immobilization for Biocatalytic Transformations
    DOI 10.1002/biot.201700542
    Type Journal Article
    Author Lechner H
    Journal Biotechnology Journal
    Link Publication
  • 2017
    Title Biocatalytic Oxidative Cascade for the Conversion of Fatty Acids into a-Ketoacids via Internal H2O2 Recycling
    DOI 10.1002/anie.201710227
    Type Journal Article
    Author Gandomkar S
    Journal Angewandte Chemie International Edition
    Pages 427-430
    Link Publication
  • 2017
    Title Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids
    DOI 10.3390/molecules22122205
    Type Journal Article
    Author Pickl M
    Journal Molecules
    Pages 2205
    Link Publication
  • 2018
    Title The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition
    DOI 10.1038/s41598-018-27051-7
    Type Journal Article
    Author Aschauer P
    Journal Scientific Reports
    Pages 8948
    Link Publication
  • 2018
    Title Genes Activated by Vibrio cholerae upon Exposure to Caenorhabditis elegans Reveal the Mannose-Sensitive Hemagglutinin To Be Essential for Colonization
    DOI 10.1128/mspheredirect.00238-18
    Type Journal Article
    Author List C
    Journal mSphere
    Link Publication
  • 2020
    Title Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids
    DOI 10.1038/s41467-020-20035-0
    Type Journal Article
    Author Pfeiffer M
    Journal Nature Communications
    Pages 6270
    Link Publication
  • 2019
    Title Closing the gap: yeast electron-transferring flavoprotein links the oxidation of d-lactate and d-a-hydroxyglutarate to energy production via the respiratory chain
    DOI 10.1111/febs.14924
    Type Journal Article
    Author Toplak M
    Journal The FEBS Journal
    Pages 3611-3628
    Link Publication
  • 2019
    Title Outer Membrane Vesiculation Facilitates Surface Exchange and In Vivo Adaptation of Vibrio cholerae
    DOI 10.1016/j.chom.2019.12.002
    Type Journal Article
    Author Zingl F
    Journal Cell Host & Microbe
    Link Publication
  • 2013
    Title Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyase
    DOI 10.1111/febs.12501
    Type Journal Article
    Author Hajnal I
    Journal The FEBS Journal
    Pages 5815-5828
    Link Publication
  • 2013
    Title Inverting hydrolases and their use in enantioconvergent biotransformations
    DOI 10.1016/j.tibtech.2013.05.005
    Type Journal Article
    Author Schober M
    Journal Trends in Biotechnology
    Pages 468-478
    Link Publication
  • 2013
    Title Functional Cardiac Lipolysis in Mice Critically Depends on Comparative Gene Identification-58*
    DOI 10.1074/jbc.m112.420620
    Type Journal Article
    Author Zierler K
    Journal Journal of Biological Chemistry
    Pages 9892-9904
    Link Publication
  • 2013
    Title Regulation of the Yeast Triacylglycerol Lipase Tgl3p by Formation of Nonpolar Lipids*
    DOI 10.1074/jbc.m113.459610
    Type Journal Article
    Author Schmidt C
    Journal Journal of Biological Chemistry
    Pages 19939-19948
    Link Publication
  • 2013
    Title Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts
    DOI 10.1021/op4000237
    Type Journal Article
    Author Kroutil W
    Journal Organic Process Research & Development
    Pages 751-759
    Link Publication
  • 2013
    Title Lipid Transport between the Endoplasmic Reticulum and Mitochondria
    DOI 10.1101/cshperspect.a013235
    Type Journal Article
    Author Flis V
    Journal Cold Spring Harbor Perspectives in Biology
    Link Publication
  • 2013
    Title Development of small-molecule inhibitors targeting adipose triglyceride lipase
    DOI 10.1038/nchembio.1359
    Type Journal Article
    Author Mayer N
    Journal Nature Chemical Biology
    Pages 785-787
    Link Publication
  • 2013
    Title Immunogenicity of Pasteurella multocida and Mannheimia haemolytica outer membrane vesicles
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    Title Genotypes of Klebsiella oxytoca Isolates from Patients with Nosocomial Pneumonia Are Distinct from Those of Isolates from Patients with Antibiotic-Associated Hemorrhagic Colitis
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    Title Inverting the Regioselectivity of the Berberine Bridge Enzyme by Employing Customized Fluorine-Containing Substrates
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    Title New Family of Biuret Hydrolases Involved in s-Triazine Ring Metabolism
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    Title Retinyl ester hydrolases and their roles in vitamin A homeostasis
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    Title A Stereoselective Inverting sec-Alkylsulfatase for the Deracemization of sec-Alcohols
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    Title The First Structure of Dipeptidyl-peptidase III Provides Insight into the Catalytic Mechanism and Mode of Substrate Binding* ?
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    Title The phosphate site of trehalose phosphorylase from Schizophyllum commune probed by site-directed mutagenesis and chemical rescue studies
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    Title Asymmetric Bioreduction of Activated C=C Bonds Using Zymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1–3 from Yeasts
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    Title Integration of enzyme, strain and reaction engineering to overcome limitations of baker's yeast in the asymmetric reduction of a-keto esters
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    Title Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
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    Title Stereocomplementary Asymmetric Reduction of Bulky–Bulky Ketones by Biocatalytic Hydrogen Transfer
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    Title Sucrose Phosphorylase Harbouring a Redesigned, Glycosyltransferase-Like Active Site Exhibits Retaining Glucosyl Transfer in the Absence of a Covalent Intermediate
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    Title Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver
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    Title Substrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity ,
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    Title ß-Cyclodextrin Improves Solubility and Enzymatic C-Glucosylation of the Flavonoid Phloretin
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    Title Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae
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    Title A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris
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    Title Exploiting Acid Phosphatases in the Synthesis of Phosphorylated Monoalcohols and Diols
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    Title Plasmid R1 Conjugative DNA Processing Is Regulated at the Coupling Protein Interface
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    Title New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation
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    Title Protein and DNA Effectors Control the TraI Conjugative Helicase of Plasmid R1
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    Journal Journal of Bacteriology
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  • 2009
    Title Phosphatidylethanolamine synthesized by three different pathways is supplied to peroxisomes of the yeast Saccharomyces cerevisiae
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    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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  • 2009
    Title Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast to mammals
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    Journal Cell Cycle
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  • 2009
    Title Good Fat, Essential Cellular Requirements for Triacylglycerol Synthesis to Maintain Membrane Homeostasis in Yeast*
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    Journal Journal of Biological Chemistry
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  • 2009
    Title Structural and Thermodynamic Characterization of Vibrio fischeri CcdB*
    DOI 10.1074/jbc.m109.068429
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    Journal Journal of Biological Chemistry
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  • 2009
    Title Growth Retardation, Impaired Triacylglycerol Catabolism, Hepatic Steatosis, and Lethal Skin Barrier Defect in Mice Lacking Comparative Gene Identification-58 (CGI-58)*
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    Author Radner F
    Journal Journal of Biological Chemistry
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  • 2009
    Title Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids
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    Journal Journal of Lipid Research
    Pages 490-499
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  • 2009
    Title Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine
    DOI 10.1016/j.phytochem.2009.06.005
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    Author Winkler A
    Journal Phytochemistry
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  • 2009
    Title Biocatalytic Friedel–Crafts Alkylation Using Non-natural Cofactors
    DOI 10.1002/anie.200905095
    Type Journal Article
    Author Stecher H
    Journal Angewandte Chemie International Edition
    Pages 9546-9548
  • 2009
    Title Tuning microbial hosts for membrane protein production
    DOI 10.1186/1475-2859-8-69
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    Author Freigassner M
    Journal Microbial Cell Factories
    Pages 69
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  • 2009
    Title Janus-faced Enzymes Yeast Tgl3p and Tgl5p Catalyze Lipase and Acyltransferase Reactions
    DOI 10.1091/mbc.e09-09-0775
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    Author Rajakumari S
    Journal Molecular Biology of the Cell
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  • 2009
    Title Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin
    DOI 10.1111/j.1476-5381.2009.00126.x
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    Author Wenzl M
    Journal British Journal of Pharmacology
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  • 2009
    Title Biochemical characterization and mutational analysis of the mononuclear non-haem Fe2+ site in Dke1, a cupin-type dioxygenase from Acinetobacter johnsonii
    DOI 10.1042/bj20081161
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    Journal Biochemical Journal
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  • 2009
    Title Biocatalytic Access to a,a-Dialkyl-a-amino Acids by a Mechanism-Based Approach
    DOI 10.1002/anie.200904395
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    Author Fesko K
    Journal Angewandte Chemie International Edition
    Pages 121-124
  • 2009
    Title Structural and Mechanistic Studies Reveal the Functional Role of Bicovalent Flavinylation in Berberine Bridge Enzyme* ?
    DOI 10.1074/jbc.m109.015727
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    Journal Journal of Biological Chemistry
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  • 2009
    Title A Novel Regulatory Protein Involved in Motility of Vibrio cholerae
    DOI 10.1128/jb.00948-09
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    Journal Journal of Bacteriology
    Pages 7027-7038
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  • 2009
    Title Analysis of Lipid Particles from Yeast
    DOI 10.1007/978-1-60761-322-0_18
    Type Book Chapter
    Author Connerth M
    Publisher Springer Nature
    Pages 359-374
  • 2009
    Title Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae
    DOI 10.1016/j.bbalip.2009.12.008
    Type Journal Article
    Author Schuiki I
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 480-486
  • 2009
    Title Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2 BIOACTIVATION OF NITROGLYCERIN AND EFFECTS OF Alda-1*
    DOI 10.1074/jbc.m109.014548
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    Journal Journal of Biological Chemistry
    Pages 943-952
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  • 2009
    Title Mechanism of Flavin Reduction and Oxidation in the Redox-Sensing Quinone Reductase Lot6p from Saccharomyces cerevisiae
    DOI 10.1021/bi900734a
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    Author Sollner S
    Journal Biochemistry
    Pages 8636-8643
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  • 2009
    Title Dissection of Contributions from Invariant Amino Acids to Complex Formation and Catalysis in the Heteromeric Pyridoxal 5-Phosphate Synthase Complex from Bacillus subtilis
    DOI 10.1021/bi801887r
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    Author Wallner S
    Journal Biochemistry
    Pages 1928-1935
  • 2009
    Title Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2*
    DOI 10.1074/jbc.m109.005652
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    Author Wenzl M
    Journal Journal of Biological Chemistry
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  • 2009
    Title Positioning of Micelle-Bound Peptides by Paramagnetic Relaxation Enhancements
    DOI 10.1021/jp808501x
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    Author Zangger K
    Journal The Journal of Physical Chemistry B
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  • 2009
    Title A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase
    DOI 10.1111/j.1742-4658.2009.07222.x
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    Journal The FEBS Journal
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  • 2009
    Title Mechanisms Underlying Activation of Soluble Guanylate Cyclase by the Nitroxyl Donor Angeli’s Salt
    DOI 10.1124/mol.109.059915
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    Journal Molecular Pharmacology
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    Title Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling*
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    Journal Journal of Biological Chemistry
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  • 2009
    Title Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5
    DOI 10.1152/ajpendo.00099.2009
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    Journal American Journal of Physiology-Endocrinology and Metabolism
  • 2008
    Title Ortho -lithiation of free ferrocenyl alcohols : a new method for the synthesis of planar chiral ferrocene derivatives
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  • 2008
    Title Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: Lack of evidence for a role in the bioactivation of nitroglycerin
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    Journal Nitric Oxide
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    Title Vacuolar functions determine the mode of cell death
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    Journal Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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    Title Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases*
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    Journal Journal of Biological Chemistry
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  • 2008
    Title Functional Roles of the 6-S-Cysteinyl, 8a-N1-Histidyl FAD in Glucooligosaccharide Oxidase from Acremonium strictum *
    DOI 10.1074/jbc.m804331200
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    Journal Journal of Biological Chemistry
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  • 2008
    Title A concerted mechanism for berberine bridge enzyme
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    Journal Nature Chemical Biology
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    Title Structural and Biochemical Properties of Lipid Particles from the Yeast Saccharomyces cerevisiae *
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    Journal Journal of Biological Chemistry
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  • 2008
    Title Synthesis and turnover of non-polar lipids in yeast
    DOI 10.1016/j.plipres.2008.01.001
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    Author Rajakumari S
    Journal Progress in Lipid Research
    Pages 157-171
  • 2008
    Title A High-Yielding Biocatalytic Process for the Production of 2-O-(a-D-glucopyranosyl)-sn-glycerol, a Natural Osmolyte and Useful Moisturizing Ingredient
    DOI 10.1002/anie.200803562
    Type Journal Article
    Author Goedl C
    Journal Angewandte Chemie International Edition
    Pages 10086-10089
  • 2008
    Title Mechanistic differences among retaining disaccharide phosphorylases: insights from kinetic analysis of active site mutants of sucrose phosphorylase and a,a-trehalose phosphorylase
    DOI 10.1016/j.carres.2008.01.029
    Type Journal Article
    Author Goedl C
    Journal Carbohydrate Research
    Pages 2032-2040
  • 2008
    Title Four types of threonine aldolases: Similarities and differences in kinetics/thermodynamics
    DOI 10.1016/j.molcatb.2007.10.010
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    Author Fesko K
    Journal Journal of Molecular Catalysis B: Enzymatic
    Pages 19-26
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    Title Structure-Function Correlations of Two Highly Conserved Motifs in Saccharomyces cerevisiae Squalene Epoxidase
    DOI 10.1128/aac.01282-07
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    Author Ruckenstuhl C
    Journal Antimicrobial Agents and Chemotherapy
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  • 2008
    Title Synthesis of ß-hydroxy-a-amino acids with a reengineered alanine racemase
    DOI 10.1016/j.bmcl.2008.08.031
    Type Journal Article
    Author Fesko K
    Journal Bioorganic & Medicinal Chemistry Letters
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  • 2008
    Title Quinone reductase acts as a redox switch of the 20S yeast proteasome
    DOI 10.1038/embor.2008.218
    Type Journal Article
    Author Sollner S
    Journal The EMBO Reports
    Pages 65-70
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  • 2008
    Title The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death
    DOI 10.1038/cdd.2008.67
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    Journal Cell Death & Differentiation
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  • 2008
    Title Asymmetric Bioreduction of C?C Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme-Based Stereocontrol
    DOI 10.1002/adsc.200700458
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    Author Hall M
    Journal Advanced Synthesis & Catalysis
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  • 2016
    Title A Kinase-Independent One-Pot Multienzyme Cascade for an Expedient Synthesis of Guanosine 5'-Diphospho-d-mannose
    DOI 10.1002/adsc.201600761
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    Author Pfeiffer M
    Journal Advanced Synthesis & Catalysis
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  • 2016
    Title A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria
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    Author Roier S
    Journal Nature Communications
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  • 2016
    Title Regulation of the yeast triacylglycerol lipases Tgl4p and Tgl5p by the presence/absence of nonpolar lipids
    DOI 10.1091/mbc.e15-09-0633
    Type Journal Article
    Author Klein I
    Journal Molecular Biology of the Cell
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  • 2016
    Title Multivalency Effects on the Immobilization of Sucrose Phosphorylase in Flow Microchannels and Their Use in the Development of a High-Performance Biocatalytic Microreactor
    DOI 10.1002/cctc.201601019
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    Author Valikhani D
    Journal ChemCatChem
    Pages 161-166
  • 2016
    Title Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability
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    Author Tongsook C
    Journal Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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  • 2015
    Title Systematic strain construction and process development: Xylitol production by Saccharomyces cerevisiae expressing Candida tenuis xylose reductase in wild-type or mutant form
    DOI 10.1016/j.biortech.2015.09.046
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    Author Pratter S
    Journal Bioresource Technology
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  • 2015
    Title Sucrose synthase: A unique glycosyltransferase for biocatalytic glycosylation process development
    DOI 10.1016/j.biotechadv.2015.11.003
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    Journal Biotechnology Advances
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  • 2015
    Title The Toxin-Producing Pathobiont Klebsiella oxytoca Is Not Associated with Flares of Inflammatory Bowel Diseases
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    Journal Digestive Diseases and Sciences
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    Title The substrate tolerance of alcohol oxidases
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    Journal Applied Microbiology and Biotechnology
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  • 2015
    Title Biocatalysts for the formation of three- to six-membered carbo- and heterocycles
    DOI 10.1016/j.biotechadv.2015.01.012
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    Journal Biotechnology Advances
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  • 2015
    Title ?-Transaminases for the amination of functionalised cyclic ketones
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    Journal Organic & Biomolecular Chemistry
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  • 2015
    Title Morphogenesis checkpoint kinase Swe1 is the executor of lipolysis-dependent cell-cycle progression
    DOI 10.1073/pnas.1423175112
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    Journal Proceedings of the National Academy of Sciences
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  • 2015
    Title An updated view on horseradish peroxidases: recombinant production and biotechnological applications
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    Journal Applied Microbiology and Biotechnology
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  • 2015
    Title a/ß Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate*
    DOI 10.1074/jbc.m115.669168
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    Journal Journal of Biological Chemistry
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  • 2015
    Title Structure of a CGI-58 Motif Provides the Molecular Basis of Lipid Droplet Anchoring*
    DOI 10.1074/jbc.m115.682203
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    Author Boeszoermenyi A
    Journal Journal of Biological Chemistry
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  • 2015
    Title Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling*
    DOI 10.1074/jbc.m114.628958
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    Journal Journal of Biological Chemistry
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  • 2015
    Title A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris
    DOI 10.1093/femsyr/fov082
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    Journal FEMS Yeast Research
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  • 2015
    Title Restriction site free cloning (RSFC) plasmid family for seamless, sequence independent cloning in Pichia pastoris
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    Journal Microbial Cell Factories
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  • 2015
    Title Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation*
    DOI 10.1074/jbc.m115.683615
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    Journal Journal of Biological Chemistry
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  • 2015
    Title Amination of ?-Functionalized Aliphatic Primary Alcohols by a Biocatalytic Oxidation–Transamination Cascade
    DOI 10.1002/cctc.201500589
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    Journal ChemCatChem
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  • 2015
    Title Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells
    DOI 10.1016/j.bbalip.2015.02.017
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    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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  • 2015
    Title Characterization of a poly(butylene adipate-co-terephthalate)-hydrolyzing lipase from Pelosinus fermentans
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    Title Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1*
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    Journal Journal of Biological Chemistry
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  • 2015
    Title Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids
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    Journal Journal of Hepatology
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  • 2015
    Title Correction: Phosphatidylcholine Supply to Peroxisomes of the Yeast Saccharomyces cerevisiae
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    Journal PLOS ONE
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    Title A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles
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    Journal Frontiers in Microbiology
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    Title A Yeast Mutant Deleted of GPH1 Bears Defects in Lipid Metabolism
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    Title Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity
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    Journal Proceedings of the National Academy of Sciences
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    Title Hydrolysis of synthetic polyesters by Clostridium botulinum esterases
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    Journal Biotechnology and Bioengineering
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    Title Probing of the reaction pathway of human UDP-xylose synthase with site-directed mutagenesis
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    Title Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
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    Journal Cell Metabolism
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    Journal Biochemical Society transactions
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    Title Inefficient spin trapping of superoxide in the presence of nitric-oxide: Implications for studies on nitric-oxide synthase uncoupling
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    Journal Free Radical Biology and Medicine
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    Title Exploring the cupin-type metal-coordinating signature of acetylacetone dioxygenase Dke1 with site-directed mutagenesis: Catalytic reaction profile and Fe2+ binding stability of Glu-69?Gln mutant
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    Journal Journal of Molecular Catalysis B: Enzymatic
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    Title Saturation–transfer–difference NMR to characterize substrate binding recognition and catalysis of two broadly specific glycoside hydrolases
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    Title Structure–function relationships for Schizophyllum commune trehalose phosphorylase and their implications for the catalytic mechanism of family GT-4 glycosyltransferases
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    Title Biochemical Evidence That Berberine Bridge Enzyme Belongs to a Novel Family of Flavoproteins Containing a Bi-covalently Attached FAD Cofactor*
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    Journal Journal of Biological Chemistry
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  • 2006
    Title Characterization of Squalene Epoxidase of Saccharomyces cerevisiae by Applying Terbinafine-Sensitive Variants
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    Journal Antimicrobial Agents and Chemotherapy
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    Title Characterization of a Thermostable NADPH:FMN Oxidoreductase from the Mesophilic Bacterium Bacillus subtilis †
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    Title Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism*
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    Title Variations of the 2-His-1-carboxylate Theme in Mononuclear Non-Heme FeII Oxygenases
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    Title Synthesis, storage and degradation of neutral lipids in yeast
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    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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    Title Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: Characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of a-d-glucose 1-phosphate
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    Title Reaction Coordinate Analysis for ß-Diketone Cleavage by the Non-Heme Fe2+-Dependent Dioxygenase Dke1
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    Title Structure and Function of YcnD from Bacillus subtilis, a Flavin-Containing Oxidoreductase † , ‡
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    Journal Biochemistry
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    Title Integrated approach for production of recombinant acetylacetone dioxygenase from Acinetobacter johnsonii
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    Title Obese Yeast: Triglyceride Lipolysis Is Functionally Conserved from Mammals to Yeast*
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  • 2005
    Title Biocatalytic Racemization of Aliphatic, Arylaliphatic, and Aromatic a-Hydroxycarboxylic Acids
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    Journal The Journal of Organic Chemistry
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    Title Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of alpha-D-glucose 1-phosphate.
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