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RESPIMMUN - Immune Modulation in Respiratory Diseases

RESPIMMUN - Immune Modulation in Respiratory Diseases

Grazyna Kwapiszewska (ORCID: 0000-0003-0518-9079)
  • Grant DOI 10.55776/DOC129
  • Funding program doc.funds
  • Status ended
  • Start October 1, 2021
  • End November 30, 2025
  • Funding amount € 2,010,296

Disciplines

Clinical Medicine (40%); Medical-Theoretical Sciences, Pharmacy (60%)

Keywords

    Respiratory Tract, Rhinosynositis, COPD, Inflammation, Bronchial Asthma, Lung Cancer

Abstract

Respiratory diseases such as lung cancer, COPD, lung fibrosis, and asthma, are a potential threat to health, life and affect several-hundred million people worldwide. Thus, respiratory diseases rank second only to cardiovascular diseases in terms of morbidity and social-economic burden. Very often, inflammation is an underlying problem and an altered, excessive immune-reaction can be observed, which seems to play an important role in pathogenesis as well as disease progression. However, to date these underlying mechanisms to several chronic lung diseases remain dramatically understudied, therapeutic options narrow and outcome poor. RESPImmun Immune Modulation in Respiratory Diseases, a new interdisciplinary PhD program starting in autumn 2021 at the Medical University of Graz, is the very first program in Austria and perhaps even within Europe, that will focus exactly on this interface between respiratory diseases, inflammation and immune modulation. By applying multidisciplinary and translational science, new therapeutic and diagnostic concepts will be developed. The gained knowledge will help to better combat infectious diseases like SARS-CoV-2 in future. Additional novel and unique aspects of RESPImmun are the inclusion of junior PIs to promote and nurture next generation researchers side- by-side to the early-stage scientists on PhD-student level, the focus on patient empowerment, and close collaboration with industrial partners to enable quick translation of generated concepts into possible therapeutic options. RESPImmun will bring about sustainable and outstanding lung research and training in Austria, fostering an internationally renowned center of excellence of lung research and patient care.

Consortium
  • Akos Heinemann, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Andrea J. Olschewski, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Christine Moissl-Eichinger, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Eva Maria Böhm, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Gerald Höfler, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Grazyna Kwapiszewska, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Gunther Marsche, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Herbert Strobl, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Horst Olschewski, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Julia Kargl, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Katharina Leithner, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
  • Leigh Matthew Marsh, Ludwig Boltzmann Gesellschaft
    consortium member (01.10.2021 - 30.11.2025)
  • Peter Valentin Tomazic, Medizinische Universität Graz
    consortium member (01.10.2021 - 30.11.2025)
Research institution(s)
  • Medizinische Universität Graz
International project participants
  • Sarah Lebeer, Katholieke Universiteit Leuven - Belgium
  • Richard Lehner, University of Alberta - Canada
  • Wolfgang Kübler, University of Toronto - Canada
  • Liliane Schäfer, Johann Wolfgang Goethe Universität Frankfurt am Main - Germany
  • Evi Kostenis, Rheinische Friedrich-Wilhelms-Universität Bonn - Germany
  • Cornelis M. Van Drunen, Academic Medical Centre Amsterdam - Netherlands
  • Jose M. Silva, Icahn School of Medicine at Mount Sinai - USA
  • Bruce S. Bochner, Johns Hopkins University School of Medicine - USA
  • Helene F. Rosenberg, National Institute of Allergy and Infectious Diseases - USA
  • Houghton Mcgarry, University of Washington - USA
  • Christopher J. Rhodes, Imperial College London

Research Output

  • 80 Citations
  • 29 Publications
  • 9 Scientific Awards
Publications
  • 2025
    Title The Acrolein-Lipopolysaccharide Mouse Model for Frequent Exacerbations in Chronic Obstructive Pulmonary Disease.
    DOI 10.1165/rcmb.2024-0507ma
    Type Journal Article
    Author Bordag N
    Journal American journal of respiratory cell and molecular biology
    Pages 343-352
  • 2025
    Title Soluble Transferrin Receptor-1 in Pulmonary Hypertension Associated with COPD.
    DOI 10.1007/s00408-025-00833-3
    Type Journal Article
    Author Curcic P
    Journal Lung
    Pages 79
  • 2025
    Title Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis.
    DOI 10.3390/antiox14060664
    Type Journal Article
    Author Madl T
    Journal Antioxidants (Basel, Switzerland)
  • 2024
    Title HDL and SARS CoV-2: emerging theragnostic implications.
    DOI 10.1016/j.molmed.2024.02.001
    Type Journal Article
    Author Rani A
    Journal Trends in molecular medicine
    Pages 425-428
  • 2024
    Title Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area.
    DOI 10.1128/spectrum.01549-23
    Type Journal Article
    Author Fischmeister Fps
    Journal Microbiology spectrum
  • 2025
    Title Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis.
    DOI 10.1073/pnas.2419568122
    Type Journal Article
    Author Haitzmann T
    Journal Proceedings of the National Academy of Sciences of the United States of America
  • 2025
    Title Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis.
    DOI 10.1152/ajplung.00286.2024
    Type Journal Article
    Author Mooslechner Aa
    Journal American journal of physiology. Lung cellular and molecular physiology
  • 2025
    Title The molecular circadian clock of eosinophils: a potential therapeutic target for asthma.
    DOI 10.1152/ajpcell.00149.2025
    Type Journal Article
    Author Bärnthaler T
    Journal American journal of physiology. Cell physiology
  • 2025
    Title Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function.
    DOI 10.1016/j.bbadva.2024.100135
    Type Journal Article
    Author Akhmetshina A
    Journal BBA advances
    Pages 100135
  • 2025
    Title Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage.
    DOI 10.1016/j.isci.2025.112966
    Type Journal Article
    Author Bordag N
    Journal iScience
    Pages 112966
  • 2024
    Title The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension.
    DOI 10.1111/bph.16426
    Type Journal Article
    Author Csáki R
    Journal British journal of pharmacology
    Pages 3576-3593
  • 2024
    Title The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation.
    DOI 10.3389/fimmu.2024.1408772
    Type Journal Article
    Author Schwanzer J
    Journal Frontiers in immunology
    Pages 1408772
  • 2024
    Title Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells.
    DOI 10.1186/s40170-024-00337-3
    Type Journal Article
    Author Haitzmann T
    Journal Cancer & metabolism
    Pages 9
  • 2024
    Title Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial.
    DOI 10.1186/s12933-024-02426-5
    Type Journal Article
    Author Obermayer A
    Journal Cardiovascular diabetology
    Pages 339
  • 2021
    Title Phospholipid dynamics in ex vivo lung cancer and normal lung explants
    DOI 10.1038/s12276-020-00547-x
    Type Journal Article
    Author Lesko J
    Journal Experimental & Molecular Medicine
    Pages 81-90
    Link Publication
  • 2022
    Title Anorexia Nervosa Is Associated with a Shift to Pro-Atherogenic Low-Density Lipoprotein Subclasses
    DOI 10.3390/biomedicines10040895
    Type Journal Article
    Author Stadler J
    Journal Biomedicines
    Pages 895
    Link Publication
  • 2024
    Title Association of Small HDL Subclasses with Mortality Risk in Chronic Kidney Disease.
    DOI 10.3390/antiox13121511
    Type Journal Article
    Author Borenich A
    Journal Antioxidants (Basel, Switzerland)
  • 2024
    Title Metabolic heterogeneity in cancer.
    DOI 10.1038/s42255-023-00963-z
    Type Journal Article
    Author Demicco M
    Journal Nature metabolism
    Pages 18-38
  • 2023
    Title A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease.
    DOI 10.3390/pharmaceutics15051504
    Type Journal Article
    Author Marsche G
    Journal Pharmaceutics
  • 2023
    Title The vascular perspective on acute and chronic lung disease.
    DOI 10.1172/jci170502
    Type Journal Article
    Author Birnhuber A
    Journal The Journal of clinical investigation
  • 2023
    Title Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming.
    DOI 10.3390/antiox12101790
    Type Journal Article
    Author Kálmán N
    Journal Antioxidants (Basel, Switzerland)
  • 2023
    Title HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function.
    DOI 10.3390/antiox12112009
    Type Journal Article
    Author Habisch H
    Journal Antioxidants (Basel, Switzerland)
  • 2022
    Title Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling.
    DOI 10.1172/jci.insight.153471
    Type Journal Article
    Author Crnkovic S
    Journal JCI insight
  • 2022
    Title Reduced olfactory performance is associated with changed microbial diversity, oralization and accumulation of dead biomaterial in the nasal olfactory area
    DOI 10.21203/rs.3.rs-2251236/v1
    Type Preprint
    Author Kumpitsch C
    Link Publication
  • 2021
    Title PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells
    DOI 10.1016/j.freeradbiomed.2021.09.007
    Type Journal Article
    Author Bluemel G
    Journal Free Radical Biology and Medicine
    Pages 34-45
    Link Publication
  • 2023
    Title Dysregulation of metabolic pathways in pulmonary fibrosis.
    DOI 10.1016/j.pharmthera.2023.108436
    Type Journal Article
    Author Atallah R
    Journal Pharmacology & therapeutics
    Pages 108436
  • 2023
    Title Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes?
    DOI 10.1183/16000617.0173-2022
    Type Journal Article
    Author Foris V
    Journal European respiratory review : an official journal of the European Respiratory Society
  • 2022
    Title Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis
    DOI 10.1016/j.pharmthera.2022.108249
    Type Journal Article
    Author Sinha M
    Journal Pharmacology & Therapeutics
    Pages 108249
    Link Publication
  • 2022
    Title Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19
    DOI 10.3390/antiox11101858
    Type Journal Article
    Author Stadler J
    Journal Antioxidants
    Pages 1858
    Link Publication
Scientific Awards
  • 2025
    Title EFIS-IL Short-term Fellowship (European Federation of Immunological Societies EFIS)
    Type Awarded honorary membership, or a fellowship, of a learned society
    Level of Recognition Continental/International
  • 2025
    Title Marietta Blau Grant (Austrian Agency for Education and Internationalisation)
    Type Awarded honorary membership, or a fellowship, of a learned society
    Level of Recognition National (any country)
  • 2024
    Title Young investigator award at the 19th International Conference on Innate Immunity
    Type Poster/abstract prize
    Level of Recognition Continental/International
  • 2024
    Title Best Poster Presentation (Medical University of Graz)
    Type Poster/abstract prize
    Level of Recognition National (any country)
  • 2024
    Title 2nd Poster Price at the PH-DACH 2023 conference
    Type Poster/abstract prize
    Level of Recognition Continental/International
  • 2024
    Title EMBO short Fellowship (European Molecular Biology Organization EMBO)
    Type Awarded honorary membership, or a fellowship, of a learned society
    Level of Recognition Continental/International
  • 2024
    Title ERS Travel Grant from the Austrian Society for Pulmonology (ÖGP)
    Type Awarded honorary membership, or a fellowship, of a learned society
    Level of Recognition National (any country)
  • 2023
    Title Young Investigators Award (Society for Free Radical Research) (June 2023)
    Type Research prize
    Level of Recognition Continental/International
  • 2023
    Title 3rd prize for basic science research at Congress of Austrian Pneumology Society (ÖGP) 2023
    Type Poster/abstract prize
    Level of Recognition National (any country)

Discovering
what
matters.

Contact

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Georg-Coch-Platz 2
(Entrance Wiesingerstraße 4)
1010 Vienna

office(at)fwf.ac.at
+43 1 505 67 40

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