RESPIMMUN - Immune Modulation in Respiratory Diseases
RESPIMMUN - Immune Modulation in Respiratory Diseases
Disciplines
Clinical Medicine (40%); Medical-Theoretical Sciences, Pharmacy (60%)
Keywords
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Respiratory Tract,
Rhinosynositis,
COPD,
Inflammation,
Bronchial Asthma,
Lung Cancer
Respiratory diseases such as lung cancer, COPD, lung fibrosis, and asthma, are a potential threat to health, life and affect several-hundred million people worldwide. Thus, respiratory diseases rank second only to cardiovascular diseases in terms of morbidity and social-economic burden. Very often, inflammation is an underlying problem and an altered, excessive immune-reaction can be observed, which seems to play an important role in pathogenesis as well as disease progression. However, to date these underlying mechanisms to several chronic lung diseases remain dramatically understudied, therapeutic options narrow and outcome poor. RESPImmun Immune Modulation in Respiratory Diseases, a new interdisciplinary PhD program starting in autumn 2021 at the Medical University of Graz, is the very first program in Austria and perhaps even within Europe, that will focus exactly on this interface between respiratory diseases, inflammation and immune modulation. By applying multidisciplinary and translational science, new therapeutic and diagnostic concepts will be developed. The gained knowledge will help to better combat infectious diseases like SARS-CoV-2 in future. Additional novel and unique aspects of RESPImmun are the inclusion of junior PIs to promote and nurture next generation researchers side- by-side to the early-stage scientists on PhD-student level, the focus on patient empowerment, and close collaboration with industrial partners to enable quick translation of generated concepts into possible therapeutic options. RESPImmun will bring about sustainable and outstanding lung research and training in Austria, fostering an internationally renowned center of excellence of lung research and patient care.
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
- Medizinische Universität Graz
- Sarah Lebeer, Katholieke Universiteit Leuven - Belgium
- Richard Lehner, University of Alberta - Canada
- Wolfgang Kübler, University of Toronto - Canada
- Liliane Schäfer, Johann Wolfgang Goethe Universität Frankfurt am Main - Germany
- Evi Kostenis, Rheinische Friedrich-Wilhelms-Universität Bonn - Germany
- Cornelis M. Van Drunen, Academic Medical Centre Amsterdam - Netherlands
- Jose M. Silva, Icahn School of Medicine at Mount Sinai - USA
- Bruce S. Bochner, Johns Hopkins University School of Medicine - USA
- Helene F. Rosenberg, National Institute of Allergy and Infectious Diseases - USA
- Houghton Mcgarry, University of Washington - USA
- Christopher J. Rhodes, Imperial College London
Research Output
- 644 Citations
- 60 Publications
- 40 Scientific Awards
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2025
Title Pan-microbiome analysis along the human respiratory axis reveals an ecological continuum in health and collapse in disease DOI 10.1101/2025.09.04.674177 Type Preprint Author Shinde T Pages 2025.09.04.674177 Link Publication -
2025
Title Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis DOI 10.1152/ajplung.00286.2024 Type Journal Article Author Rajesh R Journal American Journal of Physiology-Lung Cellular and Molecular Physiology Link Publication -
2025
Title The Acrolein–Lipopolysaccharide Mouse Model for Frequent Exacerbations in Chronic Obstructive Pulmonary Disease DOI 10.1165/rcmb.2024-0507ma Type Journal Article Author Reiter B Journal American Journal of Respiratory Cell and Molecular Biology Pages 343-352 -
2025
Title Age-related dynamics of predominant methanogenic archaea in the human gut microbiome DOI 10.1186/s12866-025-03921-9 Type Journal Article Author Mohammadzadeh R Journal BMC Microbiology Pages 193 Link Publication -
2025
Title MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-like colitis in male mice DOI 10.3389/fimmu.2025.1558079 Type Journal Article Author Vámos E Journal Frontiers in Immunology Pages 1558079 Link Publication -
2025
Title Phospholipase A2 products influence the antiplatelet functions of synthetic high-density lipoproteins DOI 10.1016/j.jlr.2025.100972 Type Journal Article Author Rodriguez A Journal Journal of Lipid Research Pages 100972 Link Publication -
2025
Title Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis DOI 10.1073/pnas.2419568122 Type Journal Article Author Schindlmaier K Journal Proceedings of the National Academy of Sciences Link Publication -
2025
Title BK channels are indispensable for endothelial function in small pulmonary arteries DOI 10.1186/s12964-025-02436-0 Type Journal Article Author Guntur D Journal Cell Communication and Signaling Pages 448 Link Publication -
2025
Title Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission DOI 10.1038/s41467-025-66821-6 Type Journal Article Author Strobl J Journal Nature Communications Pages 11715 Link Publication -
2025
Title Colonizing the clinic: tracking bacterial succession and longitudinal dynamics in five new hospital departments over an entire year. DOI 10.1128/spectrum.02178-25 Type Journal Article Author Neumann C Journal Microbiology spectrum -
2025
Title Vitamin K supports TGF-1 depended in vitro human Langerhans cell differentiation and function via Axl. DOI 10.3389/fimmu.2025.1509228 Type Journal Article Author Bauer T Journal Frontiers in immunology Pages 1509228 -
2026
Title Brepocitinib, a selective TYK2/JAK1 inhibitor, mitigates neutrophilic inflammation and glucocorticoid receptor- expression in COPD. DOI 10.1152/ajplung.00237.2025 Type Journal Article Author Bärnthaler T Journal American journal of physiology. Lung cellular and molecular physiology -
2026
Title Interleukin-23 in Lung and Airway Diseases: From Pathogenesis to Precision-Guided Therapeutic Targeting Type Journal Article Author Nayak Bb Journal Front. Pharmacol. -
2026
Title A shift in the cellular redox state redirects aspartate for export under glucose deprivation. DOI 10.1186/s40170-026-00420-x Type Journal Article Author Bluemel G Journal Cancer & metabolism -
2025
Title The molecular circadian clock of eosinophils: a potential therapeutic target for asthma. DOI 10.1152/ajpcell.00149.2025 Type Journal Article Author Bärnthaler T Journal American journal of physiology. Cell physiology -
2025
Title Expanding the cultivable human archaeome: Methanobrevibacter intestini sp. nov. and strain Methanobrevibacter smithii 'GRAZ-2' from human faeces. DOI 10.1099/ijsem.0.006751 Type Journal Article Author Mohammadzadeh R Journal International journal of systematic and evolutionary microbiology -
2025
Title Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases DOI 10.1183/16000617.0192-2024 Type Journal Article Author El-Merhie N Journal European Respiratory Review Pages 240192 Link Publication -
2024
Title Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area. DOI 10.1128/spectrum.01549-23 Type Journal Article Author Fischmeister Fps Journal Microbiology spectrum -
2024
Title Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD DOI 10.1016/j.jlr.2024.100624 Type Journal Article Author Stadler J Journal Journal of Lipid Research Pages 100624 Link Publication -
2022
Title Reduced olfactory performance is associated with changed microbial diversity, oralization and accumulation of dead biomaterial in the nasal olfactory area DOI 10.21203/rs.3.rs-2251236/v1 Type Preprint Author Kumpitsch C Link Publication -
2022
Title Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19 DOI 10.3390/antiox11101858 Type Journal Article Author Stadler J Journal Antioxidants Pages 1858 Link Publication -
2022
Title HDL Isolated by Immunoaffinity, Ultracentrifugation, or Precipitation is Compositionally and Functionally Distinct Type Journal Article Author Holzer M Journal J Lipid Res -
2021
Title Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation DOI 10.3390/biom11111629 Type Journal Article Author Guntur D Journal Biomolecules Pages 1629 Link Publication -
2021
Title PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells DOI 10.1016/j.freeradbiomed.2021.09.007 Type Journal Article Author Bluemel G Journal Free Radical Biology and Medicine Pages 34-45 Link Publication -
2025
Title Peptide-based lipid nanodiscs suppress eosinophil recruitment and chemotaxis. DOI 10.1016/j.jconrel.2025.114060 Type Journal Article Author Balandin D Journal Journal of controlled release : official journal of the Controlled Release Society Pages 114060 -
2025
Title Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage DOI 10.1016/j.isci.2025.112966 Type Journal Article Author Bordag N Journal iScience Pages 112966 Link Publication -
2025
Title Soluble Transferrin Receptor-1 in Pulmonary Hypertension Associated with COPD DOI 10.1007/s00408-025-00833-3 Type Journal Article Author Myronenko O Journal Lung Pages 79 Link Publication -
2025
Title Proteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea DOI 10.1038/s41467-025-60271-w Type Journal Article Author Weinberger V Journal Nature Communications Pages 5094 Link Publication -
2025
Title Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis DOI 10.3390/antiox14060664 Type Journal Article Author Pammer A Journal Antioxidants Pages 664 Link Publication -
2023
Title Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival DOI 10.3390/antiox12081587 Type Journal Article Author Cosic-Mujkanovic N Journal Antioxidants Pages 1587 Link Publication -
2023
Title Guilt by Association: Stepwise Entanglement of the Role of Hypoxia-inducible Factor in Pulmonary Hypertension DOI 10.1165/rcmb.2023-0103ed Type Journal Article Author Crnkovic S Journal American Journal of Respiratory Cell and Molecular Biology Pages 6-7 Link Publication -
2023
Title Dysregulation of metabolic pathways in pulmonary fibrosis DOI 10.1016/j.pharmthera.2023.108436 Type Journal Article Author Rajesh R Journal Pharmacology & Therapeutics Pages 108436 Link Publication -
2023
Title A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease DOI 10.3390/pharmaceutics15051504 Type Journal Article Author Rani A Journal Pharmaceutics Pages 1504 Link Publication -
2024
Title HDL and SARS CoV-2: emerging theragnostic implications. DOI 10.1016/j.molmed.2024.02.001 Type Journal Article Author Rani A Journal Trends in molecular medicine Pages 425-428 -
2024
Title Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function DOI 10.1016/j.bbadva.2024.100135 Type Journal Article Author Akhmetshina A Journal BBA Advances Pages 100135 Link Publication -
2024
Title First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems DOI 10.1128/msystems.01071-24 Type Journal Article Author Neumann C Journal mSystems Link Publication -
2024
Title Association of Small HDL Subclasses with Mortality Risk in Chronic Kidney Disease DOI 10.3390/antiox13121511 Type Journal Article Author Stadler J Journal Antioxidants Pages 1511 Link Publication -
2024
Title The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension DOI 10.1111/bph.16426 Type Journal Article Author Csáki R Journal British Journal of Pharmacology Pages 3576-3593 Link Publication -
2024
Title The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation DOI 10.3389/fimmu.2024.1408772 Type Journal Article Author Teppan J Journal Frontiers in Immunology Pages 1408772 Link Publication -
2024
Title Lung Fibrosis Is Linked to Increased Endothelial Cell Activation and Dysfunctional Vascular Barrier Integrity. DOI 10.1165/rcmb.2024-0046oc Type Journal Article Author Fließer E Journal American journal of respiratory cell and molecular biology Pages 318-331 -
2024
Title A comprehensive map of proteoglycan expression and deposition in the pulmonary arterial wall in health and pulmonary hypertension DOI 10.1152/ajplung.00022.2024 Type Journal Article Author Mutgan A Journal American Journal of Physiology-Lung Cellular and Molecular Physiology -
2024
Title HDL-based therapeutics: A promising frontier in combating viral and bacterial infections DOI 10.1016/j.pharmthera.2024.108684 Type Journal Article Author Rani A Journal Pharmacology & Therapeutics Pages 108684 Link Publication -
2024
Title Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells DOI 10.1186/s40170-024-00337-3 Type Journal Article Author Haitzmann T Journal Cancer & Metabolism Pages 9 Link Publication -
2024
Title Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients DOI 10.1016/j.redox.2024.103341 Type Journal Article Author Pammer A Journal Redox Biology Pages 103341 Link Publication -
2024
Title Targeting organ-specific mitochondrial dysfunction to improve biological aging DOI 10.1016/j.pharmthera.2024.108710 Type Journal Article Author Madreiter-Sokolowski C Journal Pharmacology & Therapeutics Pages 108710 Link Publication -
2024
Title Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial DOI 10.1186/s12933-024-02426-5 Type Journal Article Author Pammer A Journal Cardiovascular Diabetology Pages 339 Link Publication -
2024
Title Metabolic heterogeneity in cancer DOI 10.1038/s42255-023-00963-z Type Journal Article Author Demicco M Journal Nature Metabolism Pages 18-38 Link Publication -
2023
Title HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function DOI 10.3390/antiox12112009 Type Journal Article Author Stadler J Journal Antioxidants Pages 2009 Link Publication -
2023
Title Microenvironmental and cell intrinsic factors governing human cDC2 differentiation and monocyte reprogramming. DOI 10.3389/fimmu.2023.1216352 Type Journal Article Author Krump C Journal Frontiers in immunology Pages 1216352 -
2023
Title The vascular perspective on acute and chronic lung disease. DOI 10.1172/jci170502 Type Journal Article Author Birnhuber A Journal The Journal of clinical investigation -
2022
Title Impairment of the NKT-STAT1-CXCL9 Axis Contributes to Vessel Fibrosis in Pulmonary Hypertension Caused by Lung Fibrosis. DOI 10.1164/rccm.202201-0142oc Type Journal Article Author Jandl K Journal American journal of respiratory and critical care medicine Pages 981-998 Link Publication -
2022
Title Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis DOI 10.1016/j.pharmthera.2022.108249 Type Journal Article Author Sinha M Journal Pharmacology & Therapeutics Pages 108249 Link Publication -
2022
Title Anorexia Nervosa Is Associated with a Shift to Pro-Atherogenic Low-Density Lipoprotein Subclasses DOI 10.3390/biomedicines10040895 Type Journal Article Author Stadler J Journal Biomedicines Pages 895 Link Publication -
2022
Title Potassium Channels in the Transition from Fetal to the Neonatal Pulmonary Circulation DOI 10.3390/ijms23094681 Type Journal Article Author Nagaraj C Journal International Journal of Molecular Sciences Pages 4681 Link Publication -
2022
Title Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling. DOI 10.1172/jci.insight.153471 Type Journal Article Author Crnkovic S Journal JCI insight -
2023
Title Pentastatin, a matrikine of the collagen IVa5, is a novel endogenous mediator of pulmonary endothelial dysfunction DOI 10.1152/ajpcell.00391.2023 Type Journal Article Author Mutgan A Journal American Journal of Physiology-Cell Physiology Link Publication -
2023
Title Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming DOI 10.3390/antiox12101790 Type Journal Article Author Vámos E Journal Antioxidants Pages 1790 Link Publication -
2023
Title Endotyping COPD: hypoxia-inducible factor-2 as a molecular “switch” between the vascular and airway phenotypes? DOI 10.1183/16000617.0173-2022 Type Journal Article Author Myronenko O Journal European Respiratory Review Pages 220173 Link Publication -
2021
Title Phospholipid dynamics in ex vivo lung cancer and normal lung explants DOI 10.1038/s12276-020-00547-x Type Journal Article Author Lesko J Journal Experimental & Molecular Medicine Pages 81-90 Link Publication -
2021
Title The basement membrane in the cross-roads between the lung and kidney Type Journal Article Author Jandl K Journal Matrix Biol
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2026
Title Metabolomic Changes in High Altitute Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2026
Title Voltage, Vessels, and Vascular Remodeling: Ion Channels in Pulmonary Hypertension Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title PVRI Achievement Award 2025 Type Research prize Level of Recognition Continental/International -
2025
Title Poster Award Winner at the European Respiratory Society Seminar 2025 Type Poster/abstract prize Level of Recognition Continental/International -
2025
Title Lung Science Conference: Repairing the lung: from single cells and tissue organisation to regenerative therapy, Estoril, Portugal Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title Invited speaker Type Personally asked as a key note speaker to a conference Level of Recognition Regional (any country) -
2025
Title ATS Annual Meeting, San Francisco, USA Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title Invited speaker Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title Appointment to the editorial board of AJP Lung Type Appointed as the editor/advisor to a journal or book series Level of Recognition Continental/International -
2025
Title PVRI: Embracing Heterogeneity, Rio de Janeiro, BR Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title Grover Conference Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title 20th Anniversary Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases Conference Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title Membership ATS American Thoracic Society Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition Continental/International -
2025
Title XXV. SIRC Meeting 2025 Type Poster/abstract prize Level of Recognition Continental/International -
2025
Title Round Table discussion, UT Hospital, Houston, USA Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2025
Title PVRI Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition Continental/International -
2024
Title Pathobiology and genetics of pulmonary hypertension - update from the 7th World Symposium Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2024
Title Young investigator award at the 19th International Conference on Innate Immunity Type Poster/abstract prize Level of Recognition Continental/International -
2024
Title Appointment to the editorial board of journal AJP Cell Type Appointed as the editor/advisor to a journal or book series Level of Recognition Continental/International -
2024
Title Invited speaker Type Personally asked as a key note speaker to a conference Level of Recognition Regional (any country) -
2024
Title 2nd Poster Price at the PH-DACH 2023 conference Type Poster/abstract prize Level of Recognition Continental/International -
2024
Title Stanford University, PH Grand Rounds, Stanford, CA, USA Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2024
Title 22nd International Colloquium on Lung and Airway Fibrosis (ICLAF), Athens, GR Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2024
Title Keynote: Pathobiology and genetics of pulmonary hypertension Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2024
Title Florence P. Haseltine's Best Poster Prize (OSSD Organization for the Study of Sex Differences 2024 Conference) Type Poster/abstract prize Level of Recognition Continental/International -
2024
Title Pathobiology and genetics of pulmonary hypertension Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2023
Title 20th Years MBML, Rauischholzhausen, Germany Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2023
Title 3rd prize for basic science research at Congress of Austrian Pneumology Society (ÖGP) 2023 Type Poster/abstract prize Level of Recognition National (any country) -
2023
Title GRC Lung Development, Injury and Repair, Post-COVID Return to Respiratory Health, Waterville Valley, NH, USA Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2023
Title From pathogenesis to new management options in PH Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2023
Title Membership ERS - European Respiratory Society Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition Continental/International -
2023
Title Penn University, Philadelphia, USA Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2023
Title Outstanding Poster Award (ISAF) Type Poster/abstract prize Level of Recognition Continental/International -
2023
Title Young Investigators Award (Society for Free Radical Research) (June 2023) Type Research prize Level of Recognition Continental/International -
2023
Title Membership for ÖGP die Österreichische Gesellschaft für Pneumologie Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition National (any country) -
2023
Title Grover Conference on Precision Medicine for Pulmonary Vascular Disease: The Future Is Now, Tabernash, CO, USA Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2022
Title AHA Conference, Chicago, USA Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2022
Title 2nd PH Heart Failure Symposium, Berlin, Germany Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2022
Title AVBO (Austrian Vascular Biology Organization) Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition National (any country) -
2021
Title Appointments to the editorial board of a journal : AJRCMB Type Appointed as the editor/advisor to a journal or book series Level of Recognition Continental/International