RESPIMMUN - Immune Modulation in Respiratory Diseases
RESPIMMUN - Immune Modulation in Respiratory Diseases
Disciplines
Clinical Medicine (40%); Medical-Theoretical Sciences, Pharmacy (60%)
Keywords
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Respiratory Tract,
Rhinosynositis,
COPD,
Inflammation,
Bronchial Asthma,
Lung Cancer
Respiratory diseases such as lung cancer, COPD, lung fibrosis, and asthma, are a potential threat to health, life and affect several-hundred million people worldwide. Thus, respiratory diseases rank second only to cardiovascular diseases in terms of morbidity and social-economic burden. Very often, inflammation is an underlying problem and an altered, excessive immune-reaction can be observed, which seems to play an important role in pathogenesis as well as disease progression. However, to date these underlying mechanisms to several chronic lung diseases remain dramatically understudied, therapeutic options narrow and outcome poor. RESPImmun Immune Modulation in Respiratory Diseases, a new interdisciplinary PhD program starting in autumn 2021 at the Medical University of Graz, is the very first program in Austria and perhaps even within Europe, that will focus exactly on this interface between respiratory diseases, inflammation and immune modulation. By applying multidisciplinary and translational science, new therapeutic and diagnostic concepts will be developed. The gained knowledge will help to better combat infectious diseases like SARS-CoV-2 in future. Additional novel and unique aspects of RESPImmun are the inclusion of junior PIs to promote and nurture next generation researchers side- by-side to the early-stage scientists on PhD-student level, the focus on patient empowerment, and close collaboration with industrial partners to enable quick translation of generated concepts into possible therapeutic options. RESPImmun will bring about sustainable and outstanding lung research and training in Austria, fostering an internationally renowned center of excellence of lung research and patient care.
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
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consortium member (01.10.2021 -)
- Medizinische Universität Graz
- Sarah Lebeer, Katholieke Universiteit Leuven - Belgium
- Richard Lehner, University of Alberta - Canada
- Wolfgang Kübler, University of Toronto - Canada
- Liliane Schäfer, Johann Wolfgang Goethe Universität Frankfurt am Main - Germany
- Evi Kostenis, Rheinische Friedrich-Wilhelms-Universität Bonn - Germany
- Cornelis M. Van Drunen, Academic Medical Centre Amsterdam - Netherlands
- Jose M. Silva, Icahn School of Medicine at Mount Sinai - USA
- Bruce S. Bochner, Johns Hopkins University School of Medicine - USA
- Helene F. Rosenberg, National Institute of Allergy and Infectious Diseases - USA
- Houghton Mcgarry, University of Washington - USA
- Christopher J. Rhodes, Imperial College London - United Kingdom
Research Output
- 213 Citations
- 23 Publications
- 3 Scientific Awards
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2022
Title Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling DOI 10.1172/jci.insight.153471 Type Journal Article Author Crnkovic S Journal JCI Insight -
2022
Title Reduced olfactory performance is associated with changed microbial diversity, oralization and accumulation of dead biomaterial in the nasal olfactory area DOI 10.21203/rs.3.rs-2251236/v1 Type Preprint Author Kumpitsch C Link Publication -
2024
Title Lung Fibrosis Is Linked to Increased Endothelial Cell Activation and Dysfunctional Vascular Barrier Integrity. DOI 10.1165/rcmb.2024-0046oc Type Journal Article Author Fließer E Journal American journal of respiratory cell and molecular biology Pages 318-331 -
2024
Title A comprehensive map of proteoglycan expression and deposition in the pulmonary arterial wall in health and pulmonary hypertension DOI 10.1152/ajplung.00022.2024 Type Journal Article Author Mutgan A Journal American Journal of Physiology-Lung Cellular and Molecular Physiology -
2024
Title Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients DOI 10.1016/j.redox.2024.103341 Type Journal Article Author Pammer A Journal Redox Biology Pages 103341 Link Publication -
2024
Title Targeting organ-specific mitochondrial dysfunction to improve biological aging DOI 10.1016/j.pharmthera.2024.108710 Type Journal Article Author Madreiter-Sokolowski C Journal Pharmacology & Therapeutics Pages 108710 Link Publication -
2024
Title Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial DOI 10.1186/s12933-024-02426-5 Type Journal Article Author Pammer A Journal Cardiovascular Diabetology Pages 339 Link Publication -
2024
Title The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension DOI 10.1111/bph.16426 Type Journal Article Author Csáki R Journal British Journal of Pharmacology Pages 3576-3593 Link Publication -
2022
Title Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19 DOI 10.3390/antiox11101858 Type Journal Article Author Stadler J Journal Antioxidants Pages 1858 Link Publication -
2022
Title Anorexia Nervosa Is Associated with a Shift to Pro-Atherogenic Low-Density Lipoprotein Subclasses DOI 10.3390/biomedicines10040895 Type Journal Article Author Stadler J Journal Biomedicines Pages 895 Link Publication -
2023
Title HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function DOI 10.3390/antiox12112009 Type Journal Article Author Stadler J Journal Antioxidants Pages 2009 Link Publication -
2023
Title The vascular perspective on acute and chronic lung disease DOI 10.1172/jci170502 Type Journal Article Author Borek I Journal The Journal of Clinical Investigation Link Publication -
2023
Title Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming DOI 10.3390/antiox12101790 Type Journal Article Author Vámos E Journal Antioxidants Pages 1790 Link Publication -
2023
Title Endotyping COPD: hypoxia-inducible factor-2 as a molecular “switch” between the vascular and airway phenotypes? DOI 10.1183/16000617.0173-2022 Type Journal Article Author Myronenko O Journal European Respiratory Review Pages 220173 Link Publication -
2023
Title Pentastatin, a matrikine of the collagen IVa5, is a novel endogenous mediator of pulmonary endothelial dysfunction DOI 10.1152/ajpcell.00391.2023 Type Journal Article Author Mutgan A Journal American Journal of Physiology-Cell Physiology -
2024
Title The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation DOI 10.3389/fimmu.2024.1408772 Type Journal Article Author Teppan J Journal Frontiers in Immunology Pages 1408772 Link Publication -
2024
Title HDL and SARS CoV-2: emerging theragnostic implications DOI 10.1016/j.molmed.2024.02.001 Type Journal Article Author Rani A Journal Trends in Molecular Medicine Pages 425-428 Link Publication -
2024
Title Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells DOI 10.1186/s40170-024-00337-3 Type Journal Article Author Haitzmann T Journal Cancer & Metabolism Pages 9 Link Publication -
2024
Title Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area DOI 10.1128/spectrum.01549-23 Type Journal Article Author Kumpitsch C Journal Microbiology Spectrum Link Publication -
2023
Title Dysregulation of metabolic pathways in pulmonary fibrosis DOI 10.1016/j.pharmthera.2023.108436 Type Journal Article Author Rajesh R Journal Pharmacology & Therapeutics Pages 108436 Link Publication -
2023
Title A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease DOI 10.3390/pharmaceutics15051504 Type Journal Article Author Rani A Journal Pharmaceutics Pages 1504 Link Publication -
2022
Title Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis DOI 10.1016/j.pharmthera.2022.108249 Type Journal Article Author Sinha M Journal Pharmacology & Therapeutics Pages 108249 Link Publication -
2024
Title Association of Small HDL Subclasses with Mortality Risk in Chronic Kidney Disease DOI 10.3390/antiox13121511 Type Journal Article Author Stadler J Journal Antioxidants Pages 1511 Link Publication
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2024
Title Young investigator award at the 19th International Conference on Innate Immunity Type Poster/abstract prize Level of Recognition Continental/International -
2024
Title 2nd Poster Price at the PH-DACH 2023 conference Type Poster/abstract prize Level of Recognition Continental/International -
2023
Title 3rd prize for basic science research at Congress of Austrian Pneumology Society (ÖGP) 2023 Type Poster/abstract prize Level of Recognition National (any country)