RESPIMMUN - Immune Modulation in Respiratory Diseases
RESPIMMUN - Immune Modulation in Respiratory Diseases
Disciplines
Clinical Medicine (40%); Medical-Theoretical Sciences, Pharmacy (60%)
Keywords
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Respiratory Tract,
Rhinosynositis,
COPD,
Inflammation,
Bronchial Asthma,
Lung Cancer
Respiratory diseases such as lung cancer, COPD, lung fibrosis, and asthma, are a potential threat to health, life and affect several-hundred million people worldwide. Thus, respiratory diseases rank second only to cardiovascular diseases in terms of morbidity and social-economic burden. Very often, inflammation is an underlying problem and an altered, excessive immune-reaction can be observed, which seems to play an important role in pathogenesis as well as disease progression. However, to date these underlying mechanisms to several chronic lung diseases remain dramatically understudied, therapeutic options narrow and outcome poor. RESPImmun Immune Modulation in Respiratory Diseases, a new interdisciplinary PhD program starting in autumn 2021 at the Medical University of Graz, is the very first program in Austria and perhaps even within Europe, that will focus exactly on this interface between respiratory diseases, inflammation and immune modulation. By applying multidisciplinary and translational science, new therapeutic and diagnostic concepts will be developed. The gained knowledge will help to better combat infectious diseases like SARS-CoV-2 in future. Additional novel and unique aspects of RESPImmun are the inclusion of junior PIs to promote and nurture next generation researchers side- by-side to the early-stage scientists on PhD-student level, the focus on patient empowerment, and close collaboration with industrial partners to enable quick translation of generated concepts into possible therapeutic options. RESPImmun will bring about sustainable and outstanding lung research and training in Austria, fostering an internationally renowned center of excellence of lung research and patient care.
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
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consortium member (01.10.2021 - 30.11.2025)
- Medizinische Universität Graz
- Sarah Lebeer, Katholieke Universiteit Leuven - Belgium
- Richard Lehner, University of Alberta - Canada
- Wolfgang Kübler, University of Toronto - Canada
- Liliane Schäfer, Johann Wolfgang Goethe Universität Frankfurt am Main - Germany
- Evi Kostenis, Rheinische Friedrich-Wilhelms-Universität Bonn - Germany
- Cornelis M. Van Drunen, Academic Medical Centre Amsterdam - Netherlands
- Jose M. Silva, Icahn School of Medicine at Mount Sinai - USA
- Bruce S. Bochner, Johns Hopkins University School of Medicine - USA
- Helene F. Rosenberg, National Institute of Allergy and Infectious Diseases - USA
- Houghton Mcgarry, University of Washington - USA
- Christopher J. Rhodes, Imperial College London
Research Output
- 80 Citations
- 29 Publications
- 9 Scientific Awards
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2025
Title The Acrolein-Lipopolysaccharide Mouse Model for Frequent Exacerbations in Chronic Obstructive Pulmonary Disease. DOI 10.1165/rcmb.2024-0507ma Type Journal Article Author Bordag N Journal American journal of respiratory cell and molecular biology Pages 343-352 -
2025
Title Soluble Transferrin Receptor-1 in Pulmonary Hypertension Associated with COPD. DOI 10.1007/s00408-025-00833-3 Type Journal Article Author Curcic P Journal Lung Pages 79 -
2025
Title Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis. DOI 10.3390/antiox14060664 Type Journal Article Author Madl T Journal Antioxidants (Basel, Switzerland) -
2024
Title HDL and SARS CoV-2: emerging theragnostic implications. DOI 10.1016/j.molmed.2024.02.001 Type Journal Article Author Rani A Journal Trends in molecular medicine Pages 425-428 -
2024
Title Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area. DOI 10.1128/spectrum.01549-23 Type Journal Article Author Fischmeister Fps Journal Microbiology spectrum -
2025
Title Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis. DOI 10.1073/pnas.2419568122 Type Journal Article Author Haitzmann T Journal Proceedings of the National Academy of Sciences of the United States of America -
2025
Title Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis. DOI 10.1152/ajplung.00286.2024 Type Journal Article Author Mooslechner Aa Journal American journal of physiology. Lung cellular and molecular physiology -
2025
Title The molecular circadian clock of eosinophils: a potential therapeutic target for asthma. DOI 10.1152/ajpcell.00149.2025 Type Journal Article Author Bärnthaler T Journal American journal of physiology. Cell physiology -
2025
Title Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function. DOI 10.1016/j.bbadva.2024.100135 Type Journal Article Author Akhmetshina A Journal BBA advances Pages 100135 -
2025
Title Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage. DOI 10.1016/j.isci.2025.112966 Type Journal Article Author Bordag N Journal iScience Pages 112966 -
2024
Title The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension. DOI 10.1111/bph.16426 Type Journal Article Author Csáki R Journal British journal of pharmacology Pages 3576-3593 -
2024
Title The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation. DOI 10.3389/fimmu.2024.1408772 Type Journal Article Author Schwanzer J Journal Frontiers in immunology Pages 1408772 -
2024
Title Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells. DOI 10.1186/s40170-024-00337-3 Type Journal Article Author Haitzmann T Journal Cancer & metabolism Pages 9 -
2024
Title Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial. DOI 10.1186/s12933-024-02426-5 Type Journal Article Author Obermayer A Journal Cardiovascular diabetology Pages 339 -
2021
Title Phospholipid dynamics in ex vivo lung cancer and normal lung explants DOI 10.1038/s12276-020-00547-x Type Journal Article Author Lesko J Journal Experimental & Molecular Medicine Pages 81-90 Link Publication -
2022
Title Anorexia Nervosa Is Associated with a Shift to Pro-Atherogenic Low-Density Lipoprotein Subclasses DOI 10.3390/biomedicines10040895 Type Journal Article Author Stadler J Journal Biomedicines Pages 895 Link Publication -
2024
Title Association of Small HDL Subclasses with Mortality Risk in Chronic Kidney Disease. DOI 10.3390/antiox13121511 Type Journal Article Author Borenich A Journal Antioxidants (Basel, Switzerland) -
2024
Title Metabolic heterogeneity in cancer. DOI 10.1038/s42255-023-00963-z Type Journal Article Author Demicco M Journal Nature metabolism Pages 18-38 -
2023
Title A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease. DOI 10.3390/pharmaceutics15051504 Type Journal Article Author Marsche G Journal Pharmaceutics -
2023
Title The vascular perspective on acute and chronic lung disease. DOI 10.1172/jci170502 Type Journal Article Author Birnhuber A Journal The Journal of clinical investigation -
2023
Title Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming. DOI 10.3390/antiox12101790 Type Journal Article Author Kálmán N Journal Antioxidants (Basel, Switzerland) -
2023
Title HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function. DOI 10.3390/antiox12112009 Type Journal Article Author Habisch H Journal Antioxidants (Basel, Switzerland) -
2022
Title Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling. DOI 10.1172/jci.insight.153471 Type Journal Article Author Crnkovic S Journal JCI insight -
2022
Title Reduced olfactory performance is associated with changed microbial diversity, oralization and accumulation of dead biomaterial in the nasal olfactory area DOI 10.21203/rs.3.rs-2251236/v1 Type Preprint Author Kumpitsch C Link Publication -
2021
Title PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells DOI 10.1016/j.freeradbiomed.2021.09.007 Type Journal Article Author Bluemel G Journal Free Radical Biology and Medicine Pages 34-45 Link Publication -
2023
Title Dysregulation of metabolic pathways in pulmonary fibrosis. DOI 10.1016/j.pharmthera.2023.108436 Type Journal Article Author Atallah R Journal Pharmacology & therapeutics Pages 108436 -
2023
Title Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes? DOI 10.1183/16000617.0173-2022 Type Journal Article Author Foris V Journal European respiratory review : an official journal of the European Respiratory Society -
2022
Title Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis DOI 10.1016/j.pharmthera.2022.108249 Type Journal Article Author Sinha M Journal Pharmacology & Therapeutics Pages 108249 Link Publication -
2022
Title Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19 DOI 10.3390/antiox11101858 Type Journal Article Author Stadler J Journal Antioxidants Pages 1858 Link Publication
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2025
Title EFIS-IL Short-term Fellowship (European Federation of Immunological Societies EFIS) Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition Continental/International -
2025
Title Marietta Blau Grant (Austrian Agency for Education and Internationalisation) Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition National (any country) -
2024
Title Young investigator award at the 19th International Conference on Innate Immunity Type Poster/abstract prize Level of Recognition Continental/International -
2024
Title Best Poster Presentation (Medical University of Graz) Type Poster/abstract prize Level of Recognition National (any country) -
2024
Title 2nd Poster Price at the PH-DACH 2023 conference Type Poster/abstract prize Level of Recognition Continental/International -
2024
Title EMBO short Fellowship (European Molecular Biology Organization EMBO) Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition Continental/International -
2024
Title ERS Travel Grant from the Austrian Society for Pulmonology (ÖGP) Type Awarded honorary membership, or a fellowship, of a learned society Level of Recognition National (any country) -
2023
Title Young Investigators Award (Society for Free Radical Research) (June 2023) Type Research prize Level of Recognition Continental/International -
2023
Title 3rd prize for basic science research at Congress of Austrian Pneumology Society (ÖGP) 2023 Type Poster/abstract prize Level of Recognition National (any country)